Global ETD Search
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Showing 1 to 4 of 4 for “"KCNJ10"”.
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Differentielle Expression und Funktion eines glialen Kaliumkanals (K<sub>ir</sub>4.1, KCNJ10) im Rückenmark und Bedeutung in einem neurodegenerativen Krankheitsmodell
Innerhalb des letzten Jahrzehnts wurde immer deutlicher, dass einwärts-gleichrichtende Kaliumkanäle (Kir) neben ihrer klassischen Rolle im Aufbau und der Konstanthaltung des Ruhemembranpotentials weitere zellspezifische Aufgaben erfüllen.In der vorliegenden Arbeit konnte mittels transgener …
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The Role of Microglia and Astrocyte in Spinocerebellar Ataxia Type 1
… astrocytes and in particular, astrocytic Kir4.1/Kcnj10. Astrocytic Kcnj10 was downregulated throughout the brain of the knock-in Atxn1154Q/2Q mouse line. To investigate the potential role of cell-autonomous effects of Atxn1 on astrocytic transcription, I used the novel conditional humanized …
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The Search for Regulatory Mutations in Gitelman Syndrome
… (SLC12A3, SLC12A1, KCNJ1, CLCNKB, BSND, MAGED2, KCNJ10, CLDN10, CLDN16, CLDN19) have been linked to recessive salt wasting disorders. Gitelman syndrome (GS) is a recessive Mendelian kidney disorder caused by deleterious mutations in SLC12A3 and has an incidence of approximately 1 in 40,0002. …
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Astrocytic Sonic Hedgehog signalling in development and disease
… cells are enriched for the Shh-responsive gene KCNJ10 (Kir4.1), with overlapping proteomic expression of Shh and Kir4.1 observed near the ventricular regions. Using EdU and Ki67 staining, I elucidated a role for Kir4.1 in regulating astroglial progenitor cell proliferation and cell cycle …