Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"KCC2"”.
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Investigating KCC2 activity in Amyloid Precursor Protein (APP) associated Alzheimer’s Disease
… with the potassium-chloride cotransporter 2 (KCC2), a protein whose function is essential for healthy electrical activity in the brain. Thus, this thesis used a variety of techniques to investigate KCC2 activity in APP-associated AD. Chapter 3 established the APP-KCC2 interaction, and the …
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Immunhistochemische und funktionelle Analyse der Interaktion des neuronalen K+Cl--Kotransporters KCC2 mit dem GEF-Protein βPIX
Die Funktionalität des K+Cl--Kotransporters KCC2 ist von entscheidender Bedeutung für die Wirkung der Neurotransmitter GABA und Glyzin während der Entwicklung. Die KCC2-Transportaktivität kann über verschiedene Proteine reguliert werden. Diese können dabei entweder die Oberflächenexpression oder …
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Abnormal cortical activity leads to misallocation of GABAergic interneurons in the mouse neonatal brain.
… interneuroneiden motiliteetin alentuneen KCC2-inhibiittorille altistetuissa organotyyppisissä leikkeissä. KCC2-inhibiittori muuttaa GABAA-reseptorivälitteistä transmissiota. Meidän tuloksemme viittaavat siihen, että aivojen aktiivisuudella on tärkeä rooli myöhään syntyneiden …
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The Characterization Of Pb2+ Toxicity In Rat Neural Development: An Assessment Of Pb2+ Effects On The Gaba Shift In Neural Networks And Implications For Learning And Memory Disruption
… immunohistochemistry revealed an early shift of KCC2 expression in both cortex and hippocampus. Notably, these alterations were differentially regulated by age, brain region and subcellular circuitry within structures (i.e. DG vs. CA3). Neuronal cultures revealed that in response to Pb2+ at low …
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DISRUPTED GABA SIGNALING IN THE VENTRAL TEGMENTAL AREA DRIVES ADDICTION-LIKE BEHAVIORS
… of the potassium chloride cotransporter, KCC2, via the agonist CL290, or through serotonin 2A receptor activation is shown ex vivo and is correlated with KCC2 or 5-HT2AR agonist-mediated reduction in diazepam or alcohol consumption, respectively. In all three chapters, correction of the …
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Therapeutic Potential of Protein Kinases and Their Downstream Targets Following Traumatic Cervical Spinal Cord Injury
… kinases, which demonstrated that restoring KCC2 activity can enhance functional recovery. This work demonstrates the importance of targeted kinome-based therapeutics to alter the secondary response following traumatic SCI.
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A Role for glutamate and Gaba in attention-deficit/hyperactivity disorder: a study of the spontaneously hypertensive rat
… GLT-1, and the potassium-chloride co-transporter KCC2. The main findings of the present thesis were that glutamate-stimulated release of norepinephrine was elevated in SHR hippocampus compared to WKY and SD, and was via glutamate AMPA receptors. Elevating tonic levels of GABA in WKY and SD …
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Exploring the determinants of chloride homeostasis in neurons using biophysical models
… expression of the cationchloride cotransporter KCC2 and intracellular Cl concentration. My findings reconcile recent experimental findings and provide a framework for understanding the interplay of different chloride regulatory processes in neurons.