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Showing 1 to 20 of 45 for “"KATP"”.
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Zebrafish Models of KATP Channelopathies
… and function of ATP-sensitive potassium (KATP) channels in mammalian tissues, as well as the molecular basis of the channelopathies that result from loss-of-function or gain-of-function mutations in these channels. These studies have also highlighted that the available pharmacology to …
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Role of KATP channels in angiogenesis
… activation of ATP-sensitive potassium channels (KATP). Intriguingly, C-type Natriuretic Peptide (CNP), which is also known to activate KATP, has been reported to promote endothelial cell growth; however, its angiogenic properties have not been explored at any depth. This pattern prompted us to …
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Determining whether plasma levels of KATP channels are related to vascular function
… unknown relationship between levels of KATP channels in blood and vascular function in normal healthy subjects. <br/><br/>Methods: Blood samples were obtained and vascular function was assessed by carrying out four non-invasive tests in 50 normal healthy subjects. The levels of KATP …
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The KATP -Knockout Mouse: A Model of Susceptibility to Post-Concussion Syndrome
Approximately 1.4 million people in the United States each year sustain a mild traumatic brain injury (mTBI). Unfortunately, approximately 15% of these patients will have post- concussive symptoms that last longer than three months. Knowledge of the pathophysiological processes underlying …
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Investigation of KATP channel function in response to metabolic and pharmacological manipulation, in the hypothalamic GT1-7 cell line
… and a reduction in the sensitivity of the KATP channel to activation by MgADP. In an attempt to reverse the changes observed in KATP channel activity, the SUR1-selective KATP channel opener, NN414, was applied chronically to GT1-7 cells. However, chronic KATP channel activation severely …
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Die Rolle von KATP-Kanälen bei der evozierten Serotonin-Freisetzung während kurz- und langdauernder Blockade des Serotonin-Transporters im Neocortex der Ratte und der Maus
… im Neocortex der Ratte durch KATP-Kanal-Blockade abhängig von der Einwirkzeit der Uptake-Blocker modifiziert werden. Im Rahmen dieser Arbeit sollte geklärt werden, ob sich der [3H]-Serotonin-Release im Ratten- und Mauscortex ebenfalls durch KATP-Kanalblockade je nach Dauer der …
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Investigations into the roles of potassium channels in hair growth. Studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches.
… loss is minoxidil, an ATP-sensitive potassium (KATP) channel opener whose mechanism of stimulation is unclear. The regulatory component of KATP channels has three forms: SUR1, SUR2A and SUR2B which all respond to different molecules. Minoxidil only opens SUR2B channels, though SUR1 and SUR2B are …
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K(ATP) channel Kir62 subunit distribution differs between muscles and between fiber types in skeletal muscle
The activity of the ATP-sensitive potassium (KATP) channel, whose sensitivity to ATP and ability to permit K+ flux together allow the channel to couple the metabolic state of a cell to its membrane excitability, is important in several tissues for the maintenance of glucose homeostasis and …
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Mechanistic investigation of coordinated conformational changes in multisubunit ion channels and enzymes
… in two systems: the ATP-sensitive potassium (KATP) channel and the ATP-dependent bacterial protease, ClpAP. KATP channels consist of two protein subunits: a pore-forming subunit, Kir6.2 and a regulatory subunit, SUR1. Kir6.2 is an inwardly rectifying potassium channel, and SUR1 belongs to the …
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Membrane trafficking of ATP-sensitive potassium channels
ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is known how the number of channels at the cell …
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Die Wirkung von Antikonvulsiva auf ATP-sensitive Kalium-Kanäle
… Freisetzung Gabapen-tins durch einen Blocker des KATP-Kanals aufheben ließ. In der vorliegenden Arbeit wurde nun außer-dem dargelegt, daß bei hoher Gabapentin-Konzentration der KATP-Kanal-Agonist Pinazidil keinen zusätzlichen hemmenden Effekt auf die [3H]-Noradrenalin Freisetzung aufweisen konnte, …
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The role of ATP-sensitive inwardly rectifying potassium channels in the honey bee (Apis mellifera L.)
… for inwardly-rectifying ATP-sensitive potassium (KATP) channels in the cardiac regulation of the fruit fly antiviral immune response, but no information is available on their role in the heart-specific regulation of bee immunity. The results of this work demonstrate that KATP channel modulators …
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Neuroprotektion retinaler Ganglienzellen : Gabapentin-Laktam und die Neuropeptide NAP und Activity-dependent neurotrophic factor-9 in Kulturen isolierter Ganglienzellen und Netzhautexplantate der Ratte
… vivo, vermutlich über das Öffnen mitochondrialer KATP-Kanäle. In der vorliegenden Arbeit untersuchte ich diese Hypothese an Kulturen isolierter retinaler Ganglienzellen (RGZ). <br>RGZ neugeborener Ratten (P0 - P2) wurden mit Thy-1-Immunopanning isoliert und 48 h kultiviert. Das Überleben wurde …
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Spontaneous tone in deoxycorticosterone acetate-salt hypertensive rats
… mediated by its COX metabolites. Cromakalim, a KATP channel opener, abolished spontaneous tone in a glibenclamide-sensitive fashion. In aortic cells from DOCA-salt hypertensive rats, ATP-dependent K+(KATP) channel currents were either absent or weak in response to challenges by elevated …
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Trafficking motifs in potassium channels
The pancreatic ATP-sensitive potassium (KATP) channels couple glucose metabolism to excitability of the pancreatic β-cells to regulate insulin secretion. The channel subunits, Kir6.2 and SUR1, are encoded by the KCNJ11 and ABCC8 genes respectively. Genetic polymorphisms in these genes, which reduce …
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Osteoarthritis: the role and mechanisms of the chondroprotective peptide Urocortin I
… Kir6.1, Kir6.2, SUR1 and SUR2B subunits of the KATP channels suggesting that functional KATP channels are also present in these cells, which represent a further putative mechanism of action for UCNI. Quantitative PCR studies were performed to determine regulation of CRFR and Kir6.1 expression by …
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Photochemical harpoons: covalent labels for multi-protein complexes
… between the toxin analogue and the enzymes. The KATP channel opener, diazoxide displays marked cardioprotective effects and is reported to bind to mitochondrial KATP channels. However, the molecular structure of these channels is still largely unknown.
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Die Rolle der 14-3-3-Proteine beim Vorwärtstransport von Kaliumkanälen
… am Transport des vollständigen, heterooktameren KATP-Kanalkomplexes beteiligt sind. Die Interaktion ist dabei eng an den Multimerisierungsstatus gekoppelt und involviert Aminosäurebereiche außerhalb der ER-Lokalisationssequenz in Kir6.2. Dabei ist die Aufgabe der 14-3-3-Proteine letztlich die …
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Electrophysiological characterization of insulin secreting beta-cells in pancreatic tissue slices
… diese Übereinstimmung nicht. Weiterhin wiesen KATP-Kanäle in β-Zellen in Gewebeschnitten, verglichen mit getrennten β-Zellen, eine verringerte Sensitivität gegenüber ATP auf, wodurch die Regulation der KATP-Kanäle durch ATP in ein physiologisches Niveau verschoben wird. Zusätzlich zeigte sich, …
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Recurrent Hypoglycaemia-examining Impact and Strategy
… finding that hypothalamic ATP-sensitive K + (KATP) channels are integral to the detection of<br/>hypoglycaemia as well as instrumental to mounting a counter-regulatory response to hypoglycaemia. In a randomised, double-blind hyperinsulinaemic hypoglycaemia clamp<br/>study, I compared the …
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