Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"KAT7"”.
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The Cell-Essentiality of KAT7 in Acute Myeloid Leukemia
… CRISPR-Cas9 screens have previously identified KAT7 as an AML-specific cell-essential gene and therefore may represent a potential novel therapeutic target for AML. Here, I show that KAT7 loss leads to a rapid and dramatic global reduction in both H3K14ac and H4K12ac in association with reduced …
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Identifying Epigenetic Regulators Of Tumor Dormancy And Recurrence
… we discovered paradoxical functions of KAT7; cells with Kat7 loss were enriched during dormancy and recurrence, whereas Kat7 loss delayed recurrence, suggesting a potential biphasic effect on dormancy and recurrence. Additionally, genomic data for human breast cancer and genetically …
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RFI monitoring for the MeerKAT Radio Telescope
… There is a 7 dish radio telescope array called KAT7 which is used for bi-weekly RFI scans on the horizon. The team has two RFI trailers which provide a mobile spectrum and transient measurement system. They also have commercial handheld spectrum analysers. Most of these tools are only used …
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The Mechanisms of HOXA9-mediated Acute Myeloid Leukaemia Maintenance
… such as BCL2, DOT1L, MLLT1, JMJD1C, KAT7, I identify several other novel downstream HOXA9 targets and susceptibilities in HOXA9-driven AML that can be explored therapeutically. Utilising the acute degradation of HOXA9, I was able to disentangle the transcriptional and protein …