Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"KAP1"”.
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Molecular mechanism of KAP1-dependent transcriptional silencing
… retroelements is KRAB-associated protein 1 (KAP1, also known as TRIM28 or TIF1β). Following its recruitment to retrotransposons by sequence-specific KRAB domain-containing zinc finger proteins (KRAB-ZFPs), KAP1 induces the assembly of an epigenetic silencing complex, with chromatin remodeling …
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Functional Analysis of KAP1 Requirements for HIV-1 Transcription and Latency Reactivation
… box (KRAB)-associated protein 1 (KAP1: also named TRIM28 or TIF1β). While initial studies have revealed KAP1 to be a positive regulator of latency reversal in transformed and primary CD4+ T cells, subsequent studies have proposed KAP1 to be a repressor required for latency …
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Delineating Mechanisms of Signal-Induced RNA Polymerase II-Transcription
… acute depletion approaches to reveal that the KAP1 protein is a positive regulator of transcription of immediate early genes, a class of signal-induced genes that regulate diverse biological processes including cancer and development. Mechanistically, KAP1 negatively regulates elongation rate …
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The KRAB Zinc Finger Protein ZKSCAN3 binds to a SINE-embedded regulatory sequence to repress enhancer activity
… use their KRAB domain to recruit the cofactor KAP1, which acts as a scaffold for the induction of heterochromatin, including SETDB1- mediated H3K9Me3. However, KZFPs are increasingly recognised as being integrated into gene regulatory networks through ‘domesticating’ transposable elements to …
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THE PHD FINGER OF SP140: A STRUCTURAL AND FUNCTIONAL STUDY
… bromodomain (761-LKCE-764) and by recent data on KAP1 PHD finger, which functions as SUMO E3 ligase for the adjacent bromodomain (Ivanov et al, 2007; Zeng et al, 2008). In support to this hypothesis NMR titration experiments revealed binding of recombinant SUMO E2 ligase Ubc9 to a small, well …
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Paveldimas miežio viengubų ir dvigubų homeozinių mutantų fenotipo nestabilumas ir galimos jo priežastys /
… barley double mutants Hv-tweaky spike 2; Hooded/Kap1 (Hv-tw2;Hd) that are characterized by inherited phenotypic instability and by several new features, such as leaf-like structures, long naked gaps in the spike, and variations in the basic and ectopic flowers, which are absent in parental …
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Inherited phenotypic instability of barley homeotic single and double mutants and its possible causes /
… barley double mutants Hv-tweaky spike 2; Hooded/Kap1 (Hv-tw2;Hd) that are characterized by inherited phenotypic instability and by several new features, such as leaf-like structures, long naked gaps in the spike, and variations in the basic and ectopic flowers, which are absent in parental …
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Enzymatic Disassembly of Promoter Bound 7SK snRNP Drives Transcription Elongation of HIV and Cellular Genes
… promoters through the transcriptional regulator KAP1, which physically tethers the snRNP to promoters genome wide. Recruitment of the 7SK snRNP complex occurs after transcription initiation, allowing P-TEFb to be directly positioned for rapid extraction by TF’s upon stimuli and transferred onto …
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Characterising the interaction between TRIM28 and members of the Krab-ZFP family in transcription silencing
… transcription repression. TRIM28 (also known as KAP1 or TIF1β) functions as the co-repressor protein for the largest family of transcription factors, namely the Krüppel-associated box-containing zinc finger proteins (Krab-ZFPs). Silencing is initiated by the recruitment of TRIM28 to a target …
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A TRIM28 centric strategy to efficiently uncover the contribution of KZFPs to the evolution of gene regulatory networks
The family of KRAB zinc-finger proteins (KZFPs) is the largest group of DNA-binding factors in tetrapods and is rapidly evolving, with >350 protein-coding members in humans. While the individual roles of most human KZFPs is poorly characterized, it is known that their primary role is to …