Global ETD Search
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Showing 1 to 11 of 11 for “"K-homology"”.
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D-branes and K-homology
… close relationship between the topological $K$-homology group of the spacetime manifold $X$ of string theory and D-branes in string theory is examined. An element of the $K$-homology group is given by an equivalence class of $K$-cycles $[M,E,\phi]$, where $M$ is a closed spin$^c$ manifold, $E$ …
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The connective K theory of semidihedral groups
The real connective K-homology of finite groups ko¤(BG), plays a big role in the Gromov-Lawson-Rosenberg (GLR) conjecture. In order to compute them, we can calculate complex connective K-cohomology, ku¤(BG), first and then follow by computing complex connective K-homology, ku¤(BG), or by real …
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Positive scalar curvature and Callias-type index theorems for proper actions
… Poincaré duality for equivariant K-theory and K-homology, we are able to extend the scope of our results to include all elements of equivariant analytic K-homology, which we also show is isomorphic to equivariant geometric K-homology. Our results are applied to prove: a rigidity result for …
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L2-Indices for Perturbed Dirac Operators on Odd Dimensional Open Complete Manifolds
… as the result of pairing an element in K -homology with an element of compactly supported K -cohomology. This is achieved by putting the problem of calculating the Fredholm index of the perturbed Dirac operator in the framework of KK-theory and using the identification of K-groups with …
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Foliations and exotic index theory
… recovered via the connecting homomorphism of K-homology theory. In the case of Riemannian foliations on compact manifolds, the corona of the holonomy groupoid is a fiber bundle over the ambient manifold whose fiber is the corona of the universal leaf. By this property, an idea in the work of S. …
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Twisted stable homotopy theory
… notion of twisting leads to twisted generalized homology and cohomology and is central to the well established field of parametrized stable homotopy theory. Part II of this thesis concerns a computational problem in parametrized stable homotopy, namely the determination of the twisted K-homology …
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Structural and Functional Studies of ASCC1 in DNA and RNA Alkylation Damage Response
… ancient domains: nucleotide-binding K-Homology (KH) (associated with splicing, transcriptional regulation, and translational control) and two-histidine phosphodiesterase (PDE) (associated with hydrolysis of cyclic nucleotide phosphate bonds). Germline mutations link ASCC1 loss of …
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Fragile X Mental Retardation Protein Induces Synapse Loss Through Acute Postsynaptic Translational Regulation
… in the regulation of synapse number. An intact K homology 2 (KH2) RNA-binding domain and dephosphorylation of FMRP at S500 are required for the effects of FMRP on synapse number, indicating that FMRP-dependent translation of mRNA targets of FMRP leads to synapse loss. Furthermore, I demonstrate …
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Functional Analysis of the 15 KH Domain Human Nucleic Acid Binding Protein, Vigilin
… containing 15 related, but nonidentical K homology (KH) nucleic acid binding domains. Despite its high level of conservation among species, the precise function(s) of vigilin remain unclear. Vigilin was identified in our lab as the trans-acting factor which binds to the 3' untranslated …
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Structure and Function of KH Domain in DDX43 and DDX53 Cancer Antigen Helicases
… DEAD-box RNA helicase family, and contain a K-homology (KH) domain in their N-terminal regions and a helicase core domain in their C-terminal regions. The KH domain was first characterized in the human heterogeneous nuclear ribonucleoprotein K (hnRNP K). The typical function of KH domain is to …
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Identification of Loss of Specific FMRP-RNA Interactions as a Cause of Fragile X Syndrome
… one of the RNA-binding domains of FMRP, hnRNP K homology (KH-type) domain 2. This I304N mutation has previously been shown to abrogate RNA binding. We generated and analyzed mouse models harboring the I304N mutation. The mutant protein retains some normal activities, as it is competent to bind …