Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"K-Ras mutation"”.
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Quantitative analysis of K-ras mutation in urine as an indicator of disease status in patients with stage II or higher colorectal cancer
Thesis (M.S.)--Michigan State University. Department of Clinical Laboratory Sciences, 2008
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DISSECTING THE ROLE OF NEDD4 HECT E3 LIGASE AND ITS ISOFORMS IN CANCER
… context dependent and interesting data linked K-RAS activation to NEDD4 overexpression and subsequent PTEN degradation in human colorectal cancer. Since NEDD4 is overexpressed in Non-Small Cell Lung cancer (NSCLC), and high percentage of these tumors show K-RAS mutation, we decided to verify the …
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Nuclear Receptors in Lung Cancer
… epithelial cells (HBEC3) and in transgenic K-rasV12 mice, a well-known genetic model for lung adenocarcinoma. In the HBEC3 panel, the induced expression of peroxisome proliferator activating receptor gamma (PPARγ) in the parental HBEC3 introduced by oncogenic K-rasV12 is decreased in a subset …
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The Mechanism of Tumorigenesis In The Immortalized Human Pancreatic Cell Lines: Cell Culture Models of Human Pancreatic Cancer
… identified in PDAC include activation of K-ras (90%) and Her2 (70%), loss of p16 (95%) and p14 (40%), inactivation p53 (50-75%) and Smad4 (55%). However, the role of these signature gene alterations in PDAC is still not well understood, especially, how these genetic lesions individually or …
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The effect of RAN inhibition on human colorectal cancer cells (CRC)
… metastasise to the liver through the effect of K-Ras and Pten mutation (Mt.) (Abbas et al. 2020). This study aimed to assess the hypothesis that the Ran inhibitor mebendazole MBZ reduces cell invasion and metastasis of CRC. I have investigated MBZ effect on the CRC isogenic human cell lines with …