Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"K+ channel"”.
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Regulation of Ca2+-Activated K+ Channel: Changes with Development
… in response to iberiotoxin, a selective BK channel blocker, is significantly different between adult and fetal VSMCs. Our study of basilar VSMCs in whole-cell preparations showed that the total outward current density of fetal myocytes (57.9 ± 6.7 pA/pF) was greater than that of the adult …
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Voltage-dependent gating at the selectivity filter of the MthK K+ channel.
Voltage-dependent K+ channels can undergo a gating process known as C-type inactivation. This type of gating consists of entry into a nonconducting state that may involve conformational changes near the channel's selectivity filter. However, the details of the underlying mechanisms are not clear. …
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Investigating the Impact of K+ Channel Expression on Mechanosurveillance of Disseminated Cancer Cells
… of the large conductance potassium efflux (BK) channels, as regulators of cellular stiffness downstream of myocardin related transcription factor A (MRTFA). In primary pericytes, KCNMB1 knockdown increased cellular stiffness, which is consistent with the role of potassium efflux in promoting …
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Cardiac PI3Kα Signaling and K+ Channel Regulation in Cardiac Hypertrophy and Heart Failure
… encoding the underlying K<super>+</super> channel subunits. Importantly, additional experiments demonstrated that the transcriptional upregulation of myocardial K<super>+</super> channel expression in response to exercise or augmented PI3Kα signaling is independent of cellular hypertrophy …
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Regulation of a two-pore K+ channel by multiple subunits in Caenorhabditis elegans
K+ channels generate and tune the electrical signals that underlie the functioning of neurons and other excitable cells. We have studied a set of genetically-interacting genes, sup-9, sup-10 and unc-93, whose products are predicted to form a protein complex that when misregulated leads to severe …
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
… trigger effectors such as the mitochondrial KATP channel – however, the role of the mitochondrial BKCa channel in adenosine receptor-mediated cardioprotection has not been investigated. GPCR assays provided evidence for functional expression of Gi-coupled adenosine A1 and κ-opioid receptors, …
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Lighting up life : fluorescence studies of the Shaker K⁺ channel and myosin V in action
Submitted by Meng Tao (mengtao2@illinois.edu) on 2012-11-14T18:31:06Z No. of bitstreams: 1 Snyder_G.pdf: 2503154 bytes, checksum: f5a1b46abcce638cc410d021a34eed05 (MD5)
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Studies on the stimulant action of human gamma-globulin on spontaneous contractility: interaction with K⁺-channel openers and postaglandin inhibitors
… portal vein. Glibenclamide, a potassium channel antagonist, potentiated the action of human gamma-globulin on the portal vein by 45% and on its own had a biphasic (increase followed by a decrease) effect on the spontaneous activity of the portal vein . Glibenclamide and human …
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Angiotensin's Role in Hypoxic Injury
… sodium azide-induced apoptosis. We show that K+ channels are required for AT2 receptor neuroprotection and more specifically the actions of the delayed rectifier K+ channel. We suggest that the yielding ionic effect resulting from the activation of the delayed rectifier K+ channel, was a …
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Biochemical Studies on the Catalytic Cycle of Cytochrome C Oxidase in Rhodobacter Sphaeroides
… from Paracoccus denitrificans reveals two proton channels leading to the binuclear center. (Iwata, S., Ostermeier, C., Ludwig, B., & Michel, H. (1995) Nature 376, 660--669) One channel is referred to as the K-channel after the highly conserved lysine-362 located within it. The other channel is …
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Examining the Proton Channels in Heme -Copper Oxidases
… enzyme KI-362M indicated that a block in the K-channel would result in the blockage of the catalytic cycle between the oxidized state and the two electron reduced state. This blockage occurs because an electron cannot enter the binuclear center without a proton to maintain the charge balance. If …
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Luminescence Resonance Energy Transfer Studies of the Shaker Potassium Voltage-Gated Ion Channel
"Members of the superfamily of voltage-gated ion channels are the molecular components underlying electrical excitability in nerves and muscle. Voltage-gated channels allow the selective flow of ions across the hydrophobic lipid bilayer of a cell, opening and closing in response to changes in the …
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Interactions between potassium channels and serotonin in pulmonary arterial hypertension
… vasculature. The activity of potassium ion (K+) channels plays a major role in influencing pulmonary artery tone by regulating resting membrane potential, intracellular Ca2+ concentration and contraction of vascular smooth muscle. This study aimed to investigate possible interactions between 5-HT …
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K+-Homöostase und kaliumabhängige Xylogenese in Populus tremula L. x Populus tremuloides Michx
… wurden mit PTK2 (Populus tremula K+ channel 2), KPT1 (K+ channel Populus tremula 1) und PtKUP1 (Populus tremula K+ uptake transporter 1) drei Volllängen putativer Kaliumtransporter isoliert. PTK2 ließ sich anhand der abgeleiteten Aminosäuresequenz der AKT2/3-Unterfamilie und KPT1 dem …
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Studies of Cytochrome C Oxidases From Rhodobacter Sphaeroides and Vibrio Cholerae
… cbb 3--type oxidase contains only one proton channel (K-channel analogue) which consists of its own conserved residues. The putative K-channel related residues were tested by site-directed mutagenesis and all shown to be important for catalytic activity. ICP-OES analysis in this study …
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Studies of cytochrome c oxidases from Rhodobacter sphaeroides and Vibrio cholerae
… that cbb3–type oxidase contains only one proton channel (K-channel analogue) which consists of its own conserved residues. The putative K-channel related residues were tested by site-directed mutagenesis and all shown to be important for catalytic activity. ICP-OES analysis in this study …
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An electrophysiological study of ion transport across the isolated perfused malpighian tubule of Onymacris plana
… of DNP, chloride free Ringers, BaCl² (a K⁺-channel blocker), low (25 mM) and high (130 mM) pntassium Ringers (bathing medium), cyclic-AMP and a corpora cardiaca homogenate (CCH) on. the transepithelial resistance and the fractional resistances of the basolateral and apical membranes were …
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The role of specific voltage-activated and calcium-activated potassium currents in shaping motor neuron firing output during rhythmic motor activity
… we must target manipulations of specific ion channels to MNs. We used the Drosophila larval model system because the genetic tools available allow us to do just that. We targeted manipulations of specific calcium (Ca²⁺)-activated and voltageactivated K⁺ currents to identified populations of …
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Study of the Proton Pumping Mechanism of the Aa3-Type Cytochrome C Oxidase
… of the membrane through two proton conductive channels (D-channel and K-channel). C cO is also a redox-driven proton pump, i.e., the free energy produced by O2-reduction reaction is coupled to the pumping of four other protons through the proton conductive channel (D-channel) across the …
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