Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"K+ Channels"”.
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Expression and Function of Ca2+-Activated K+ Channels in Uterine Arteries
… that calcium-activated potassium (KCa) channels play an essential role in uterine vascular adaptation to pregnancy, which is inhibited by chronic hypoxia during gestation. Uterine arteries (UAs) were isolated from nonpregnant ewes (NPUAs) and near-term pregnant ewes (PUAs) that had been …
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Structural and Functional Studies of SLO K+ Channels: Mechanisms of Gating by Intracellular Signaling
<p>Eukaryotic K<sup>+</sup> channels from the SLO family (SLO1, SLO2 and SLO3) provide a link between intracellular signaling and the electrical activity of a cell. The opening and closing (gating) of the three different SLO homologs is controlled by the synergistic action of membrane voltage and …
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Ca2+-Activated K+ Channels in Urinary Bladder Smooth Muscle: Functional Role and Potential as Therapeutic Targets for Overactive Bladder
… conditions, the opening of potassium (K+) channels causes membrane hyperpolarization and limits the entry of Ca2+ and thus decreases DSM contractility. Among the various K+ channels, Ca2+-activated K+ (KCa) channels are important in regulating DSM function. Based on their biophysical …
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Effects of a Pharmacological Activator of Ca2+-activated K+ Channels (KCa2/3) on Recovery from Acute Myocardial Infarction in Mice
… post-MI heart, due to the expression of KCa3.1 channels within pro-inflammatory immune cells such as monocytes, neutrophils and macrophages.
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Short-term recovery from a volume increase in the mouse zygote: Characteristics of regulatory volume decrease in vitro.
… via separate but functionally coupled Cl- and K+ channels. The objectives of this thesis were to further determine some of the characteristics of these Cl- and K+ channels involved in RVD in the mouse zygote. It was proposed that the Cl - channel in mouse zygotes was a swelling-activated Cl …
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Regulation of a two-pore K+ channel by multiple subunits in Caenorhabditis elegans
K+ channels generate and tune the electrical signals that underlie the functioning of neurons and other excitable cells. We have studied a set of genetically-interacting genes, sup-9, sup-10 and unc-93, whose products are predicted to form a protein complex that when misregulated leads to severe …
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A mathematical study of the role of calcium in the regulation of saliva secretion
… cells. We investigate how the distribution of K⁺ channels affects the rate of primary saliva secretion. Maximum saliva secretion is hypothesised to occur when a small amount of K⁺ conductance is located in the apical membrane, with the majority in the basolateral membrane. Apical K⁺ channels have …
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The functional effects of barium and hypoxia on the in vitro respiratory activity
… barium, presumablydue to the closing of K+ channels and a reduction in K+ conductance.
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Molecular mapping of the rabbit atrioventricular node
… to measure levels of mRNA for specific ion channels and membrane proteins in the rabbit AVN and surrounding atrial and ventricular tissue. Neurofilament-M (NF-M) immunolabelling revealed a tract of cells extending from the posterior nodal extension through the compact node to the common …
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Interactions between potassium channels and serotonin in pulmonary arterial hypertension
… vasculature. The activity of potassium ion (K+) channels plays a major role in influencing pulmonary artery tone by regulating resting membrane potential, intracellular Ca2+ concentration and contraction of vascular smooth muscle. This study aimed to investigate possible interactions between 5-HT …
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Angiotensin's Role in Hypoxic Injury
… sodium azide-induced apoptosis. We show that K+ channels are required for AT2 receptor neuroprotection and more specifically the actions of the delayed rectifier K+ channel. We suggest that the yielding ionic effect resulting from the activation of the delayed rectifier K+ channel, was a …
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Circadian rhythms of redox state and regulation of neuronal excitability in suprachiasmatic nucleus of rodents
… of SCN neurons via changes in multiple K+ channels. The redox regulation of neuronal excitability gates the SCN sensitivity and response to entraining signals of light, by modulating Ca2+ signaling in response to excitatory neurotransmission, targeting on a ryanodine receptor–dependent …
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Avaliação da atividade espasmolítica das partes aéreas e das raízes de Solanum paniculatum L.: um estudo comparativo.
… contractile agents are the voltage - gated Ca 2+ channels (Ca V ), we investigated their involvement in mechanism of action of SP - EtOH PA , n = 5 . The control cumulative curves of CaCl 2 were diverted to the right a non - parallel form and reduction of the E max to 100% fo 27.7 ± 3.0% and EC 50 …
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Voltage-dependent gating at the selectivity filter of the MthK K+ channel.
Voltage-dependent K+ channels can undergo a gating process known as C-type inactivation. This type of gating consists of entry into a nonconducting state that may involve conformational changes near the channel's selectivity filter. However, the details of the underlying mechanisms are not clear. …
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Studies on the role of the autonomic nervous system in airway hyperreactivity.
… study focussed on the contribution of K+ -ion channels and Ca2+ - dependent processes to AH, in a guinea-pig model of asthma. Cromakalim, a potassium channel opening drug, attenuated vagally-mediated constriction in vitro in both normal and sensitized guinea-pig trachea, suggesting that the …
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Developmental regulation of smooth muscle contraction in the urinary bladder
… from the extracellular space via L-type calcium channels in both adult and newborn tissue. The contractile machinery of the newborn’s bladder tissue is more sensitive to calcium which enables contractions at lower intracellular and extracellular calcium concentrations. Non-muscle myosin is …
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Modulation of Cerebral Artery Smooth Muscle BK Channel Function by Neurosteroids
<p>Voltage-gated and Ca2+ activated K+ channels of large conductance (BK) channels are essential for many key physiological processes, such as controlling the contraction of smooth muscle, including cerebrovascular smooth muscle. Importantly, BK channels are made up of a homotetramer of α subunits …
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Luminescence Resonance Energy Transfer Studies of the Shaker Potassium Voltage-Gated Ion Channel
"Members of the superfamily of voltage-gated ion channels are the molecular components underlying electrical excitability in nerves and muscle. Voltage-gated channels allow the selective flow of ions across the hydrophobic lipid bilayer of a cell, opening and closing in response to changes in the …
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Repositioning of astemizole for malaria
… gene (hERG) encoded potassium (K+) channels. This liability led to the withdrawal of AST in most countries during the late 1970's and it is still being discontinued for use in some countries to date.
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