Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Juvenile mice"”.
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Functional Characterization of Hippocampal Synapses in a Mouse Mutant of the Dystrobrevin Binding Protein 1 (DTNBP 1) Gene
… of hippocampal synapses in sandy mice, which contain a spontaneous deletion in the DTNBP 1 gene resulting in the loss of expression of dysbindin, the protein that it encodes. I had observed enhanced excitatory basal synaptic transmission at the CA3-CA1 connection of juvenile mice, …
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Immunotoxicological Evaluation Of Critical Windows Of Development Following Exposure to 1,2:5,6 Dibenzanthracene in B6C3F1 Mice
… stages of immune system development. Adult mice were administered DBA daily in corn oil at dose levels of 158, 500, 1580, and 5000 µglkg S.C. for 28 days. Immunosuppression was not observed at levels less than 5000 µgkg in the following immune parameters: NK cell activity, anti-CD3 …
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ATM plays multiple roles in crossover regulation during mouse spermatogenesis
… might regulate crossover number, particularly in juvenile mice that exhibit reduced crossovers, referred to as the juvenile paternal age defect. During meiosis, ATM is known to negatively regulate SPO11-generated DNA double-strand breaks (DSBs). In mice, complete loss of ATM causes spermatocyte …
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Modulation of bio-behaviors and diabesity by dietary factors
… function by a high fat diet. C57BL/6J male mice were fed a 60% fat diet (high fat diet; HFD) or a 10% fat (low fat diet; LFD) for 1 or 3 weeks post-weaning, after which mice were subjected to behavioral testing. HFD-fed mice had increased anxietal-like and reward seeking behavior and …
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Unravelling the impact of early-life nutrition on microbiota-gut-brain axis signalling
… at the level of neuroimmune interactions in the juvenile brain. Our data shows that immune system priming in the gut and the periphery is aberrant in response to altered delivery mode, with implications for microglia activation in the male juvenile mouse brain. This highlights the timeframe …
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Neural Computation Through Synaptic Dynamics in Serotonergic Networks
… recording from hippocampal CA1 neurons in juvenile mice, where they reveal fundamental tradeoffs between release probability, number of synapses sampled, and statistical power. 2. Synaptic dynamics and population computations in the serotonin system. This part is comprised of two …
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ONTOGENY AND NEURAL MECHANISMS OF VOCAL COMMUNICATION IN MUS MUSCULUS
… ontogeny of vocal communication in laboratory mice (Mus musculus) provides a tractable opportunity to begin to understand the behavioral and neural mechanisms that underlie this transition in vocal communication. A wide range of transgenic tools are available in mice, offering a unique …
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Exploring Neural Activities in the Prefrontal Cortex of Fragile X Syndrome Mouse Models Using Electroencephalography
… in preclinical models—especially in female mice—remains unclear. This thesis aimed to characterize oscillatory alterations in female Fmr1 knockout (KO) mice on a C57BL/6J background and to evaluate whether EEG-derived metrics align with human findings. Analyses of spectral power, peak alpha …
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Pesticides and pesticide combinations on brain neurochemistry
… stress and that this would be greater in mice exposed early and later in life than mice exposed only as adults. We studied the effects of permethrin (PR) (a pyrethroid type I) and endosulfan (EN) (an organochlorine) on the levels of catecholamines, indolamines, acetylcholinesterase, lipid …
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Dietary tomato carotenoids and β-carotene-15,15'- dioxygenase (Bco1) genotype alter androgen metabolism, lipid metabolism, and prostate cancer progression in mice
… signaling. Male wild-type (WT) and Bco1-/- mice were raised on carotenoid-free AIN-93G diets before sacrifice between 10-14 weeks of age. We observed a significant reduction in serum testosterone levels due to Bco1-/- genotype, accompanied by significantly reduced weights of the prostate and …