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Showing 1 to 5 of 5 for “"Junin virus"”.
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Genetic Determinants of Junin Virus Attenuation
The New World arenavirus Junin (JUNV) is the causative agent of the Argentine hemorrhagic fever (AHF), a deadly disease endemic to central regions of Argentina. The live-attenuated Candid #1 strain of JUNV is currently used to vaccinate human population at risk. However, the mechanism of …
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Mechanisms of attenuation of the live Junin virus vaccine strain, Candid #1
Millions of individuals are at risk of arenavirus infection worldwide, with untreated infections often resulting in potentially lethal disease. Junin virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), is currently the only pathogenic arenavirus for which a vaccine is currently …
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A Recombinant Vesicular Stomatitis Virus Expressing the Junin Virus Glycoprotein for Arenavirus Countermeasure Development
Arenaviruses are pathogens of biodefense importance due to their potential for aerosol transmission and mortality rates reaching 30%. Here, we evaluated the use of a recombinant vesicular stomatitis virus expressing the Junin virus glycoprotein (rVSVΔG-JUNVGP) for the development of countermeasures …
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The introduction of incompatibility between Junin virus Z protein and other viral proteins results in impaired replication and attenuation
The genus Mammarenavirus with the family Arenaviridae contains many species that are pathogenic in human hosts. Among these, Junin virus (JUNV) is a New World mammarenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). AHF resulted in 15-20% case fatality during epidemics until …
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Genetic diversity and taxonomical relationships among the tacaribe serocomplex viruses (family arenaviridae)
… of the North American Tacaribe serocomplex viruses (family Arenaviridae), 2) extend our knowledge of the genetic diversity of the Tacaribe serocomplex viruses, and 3) establish genetic criteria for species demarcation within the Arenaviridae. Study 1 -- The results indicated that Neotoma …