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Showing 1 to 1 of 1 for “"Jumonji Domain-Containing Histone Demethylases"”.
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
… mechanistic path leading to SCLC death following Jumonji inhibition. Additional analysis revealed that JIB-04-resistant cells also activated pro-survival pathways such as mTOR to overcome the effects of JIB-04 treatment. I also found that the loss of KDM4A in a SCLC cell line led to slower …