Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Joint injury"”.
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Mouse models of osteoarthritis and joint injury
… articular cartilage and subchondral bone in the joints. The complexity of the disease makes the use of human models impractical and complicated. Therefore, various animal models have been developed to study the progression of OA and possible therapeutic techniques. Of those models, mouse models …
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Effects of joint capsule tissue on cartilage degradation in an in vitro joint injury model
… is a degenerative disease of the whole joint that affects an estimated 20.7 million Americans. Traumatic joint injury causes an increase in risk for the development of osteoarthritis. A previously developed model system involving co-culture of injured cartilage with joint capsule tissue …
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In vitro models of cartilage degradation following joint injury : mechanical overload, inflammatory cytokines and therapeutic approaches
Osteoarthritis (OA) is the most common form of joint disorder. Individuals who have sustained an acute traumatic joint injury are at greater risk for the development of OA. The mechanisms by which injury causes cartilage degradation are not fully understood, but the elevated levels of …
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Evaluating the Structural and Functional Consequences of Traumatic Joint Injury and their Relation to NF-κB in a Non-Invasive Model of Post-traumatic Osteoarthritis
… painful and debilitating disease of the synovial joint, characterized by degenerative changes to various joint tissues following traumatic joint injury. While several risk factors have been identified in the symptomatic progression of PTOA following injury, inflammation and NF-κB mediated changes …
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Chondrocyte response to in vitro mechanical injury and co-culture with joint capsule tissue
Acute traumatic joint injury in young adults leads to an increased risk for the development of osteoarthritis (OA) later in life irrespective of surgical intervention to stabilize the injured joint. Although the mechanism by which injury leads to joint degeneration remains to be elucidated, several …
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In vitro model of injury/cytokine-induced cartilage catabolism modulated by dynamic compression, growth factors, and glucocorticoids
… However, risks factors include traumatic joint injury that results in immediate upregulation of inflammatory cytokines within the joint, as well as direct mechanical damage to the cartilage, factors known to contribute to the onset of OA and its progression. The first aim of this thesis …
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A potential biologic role for the meniscus in the development of osteoarthritis.
… that inflammatory factors associated with joint injury would stimulate menisci to increase production of matrix-degrading enzymes, cytokines and chemokines, which could contribute to joint tissue destruction and subsequent development of osteoarthritis. We examined meniscus pathology in …
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Cartilage response to in vitro models of injury in combination with growth factor and antioxidant treatments
… States. Post-traumatic arthritis occurs after joint injury (e.g., ACL rupture or intraarticular fracture) and makes up a substantial proportion of the population with arthritis. In previous clinical studies, patients suffering from a traumatic joint injury have shown an increased risk in …
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Proteoglycan-4 in Equine Joint Disease, Exercise, and in vitro Cartilage Repair
… lubrication. The biological consequences of joint injury or disease such as osteoarthritis (OA) may include altered concentration, structure, and function of PRG4 and HA, leading to degraded SF quality and function, changes which are not fully understood. Furthermore, the effects of joint …
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Theoretical prediction of joint reaction force in a dynamic general 3-d pendulum tree model for human or animal motion
… coordinates are applied to predict dynamic joint reaction forces in an idealized flexible model of a branched 3-D pendulum tree system. The number of segments and joints on the tree are adjustable as is the branching tree pattern. The segments that comprise the tree are assumed to be one- …
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Mechanical injury and inflammatory cytokines affect cartilage integrity and tissue homeostasis : a mass spectrometric analysis of proteins with relevance to arthritis
Osteoarthritis is characterized by synovial joint degeneration, and its cardinal pathological feature is degeneration and loss of the articular cartilage joint surface. While the aetiology of osteoarthritis is unknown, risk factors include gender, age, obesity, and prior joint injury. Joint …
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Transport of proteins, biopharmaceuticals and small pharmaceutical compounds into normal and injured cartilage by Sangwon Byun.
Traumatic joint injury can induce acute damage to cartilage and surrounding joint tissues accompanied by an inflammatory response, which can significantly increase the risk of developing Qsteoarthritis. The mechanism by which joint injury results in disease development is not fully understood. …
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In vitro models for injurious compression of bovine and human articular cartilage
Patients who have sustained a traumatic joint injury, such as a ligament rupture or cartilage fracture, are known to have an increased risk for the development of osteoarthritis (OA) in that joint. This has motivated the use of in vitro models of mechanical cartilage injury in order to identify …
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Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
… of cartilage often triggered by a traumatic joint injury, such as a tear of the meniscus or anterior cruciate ligament (ACL). Such impact injuries lead to elevated levels of inflammatory cytokines in the synovial fluid of the joint, including IL-1, IL-6, and TNFa. In turn, these cytokines …
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Theoretical framework for predicting joint reaction and ground reaction forces in a dynamic pendulum tree model of human motion
… coordinates are applied to find ground and joint reaction forces on the human body modeled as a general branched 2-D pendulum tree system with arbitrary segments and arbitrarily distributed point masses. A theoretical framework is established for predicting these constraint forces during …
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Design and analysis of fiber reinforced elastomeric enclosures with application in upper arm orthosis
… for ambulation, thereby reducing the risk of joint injury. It forms an alternate load path between the crutch and the forearm, circumventing the wrist. The constricting force generated by the sleeve on the arm is analyzed by a string model and validated with experiments.
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Use Of synthetic solid scaffolds to mechanically support a chondrocyte-seeded peptide hydrogel for articular cartilage repair
… with cartilage defects caused by traumatic joint injury. Because articular cartilage has a limited innate healing response, due to its avascular, aneural, and alymphatic nature, these defects lead to chronic degenerative joint disease if left untreated. Current treatments to repair articular …
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The Effects of Cryotherapy on Quadriceps Corticospinal Excitability in Patients withPatellofemoral Pain
… to enhance corticospinal excitability following joint injury.
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Mechanical and Biologic Impact of Dynamic Loading on Bovine and Human Models of Osteoarthritis
… disease initiation (e.g., after a traumatic joint injury) and in ameliorating progression of OA. We hypothesized that Dex and IGF-1 could help to maintain the mechanical properties and biochemical composition of cartilage in human osteochondral tissues when treated with exogenous inflammatory …
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Inflammatory and Immune Effects of Intra-Articular Mesenchymal Stem Cells in Horses
… as well as modest efficacy in animal models of joint injury, warranting further study as a potential treatment of equine joint disease. The goal of the study is to investigate the inflammatory and immune response to intra-articular injection of autologous, genetically modified (bone …
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