Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Jmjd3"”.
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Rejuvenation of The Epigenetic Landscape of The Aged Brain Through Manipulation of Circulating Factors
… simultaneous loss of the opposing function of Jmjd3, thereby leading to a respective increase in H3K27me3 and decrease in H3K27me1 in the brain with age. Furthermore, when we examined the role of Ezh2 in primary microglia cultures <em>in vitro</em>, we found that inhibition of Ezh2 could …
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Heterogeneity and Impaired IGF1R Signalling in Aged B cell Development
… inhibitors to the histone H3K27 demethylase JMJD3, and the methyltransferase Ezh2, has also provided evidence to support a hypothesis of polycomb-mediated IGF1R signalling suppression in ageing B cell progenitors. Finally, I provide scope for clinical translation from these aged murine …