Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"JmjC"”.
-
Role of Chromatin Structure and JmjC Histone Demethylases in the Response to Hypoxia
… changes is ill defined. The Jumonji C (Jmjc) histone demethylases are oxygen dependent enzymes and represent a potential link between chromatin structure and oxygen sensing. Many of these enzymes are differentially expressed in hypoxia and some have been found to influence the hypoxic …
-
JMJC Domain-Containing Histone Demethylase 2 (Jhd2): Bridging the Gap between H3K4 Trimethylation and H3 Acetylation
<p>Gene expression has been shown to be regulated through epigenetic modifications to the N-terminal tail of histones. Among these modifications is methylation of lysine residues. The enzyme Jhd2 is a histone demethylase that functions to remove H3K4 methylation in S. cerevisiae. Jhd2 is a …
-
JMJC Domain-Containing Histone Demethylase 2 (Jhd2): Bridging the Gap between H3K4 Trimethylation and H3 Acetylation
Gene expression has been shown to be regulated through epigenetic modifications to the N-terminal tail of histones. Among these modifications is methylation of lysine residues. The enzyme Jhd2 is a histone demethylase that functions to remove H3K4 methylation in S. cerevisiae. Jhd2 is a homologue …
-
Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
… the response phenotypes of etoposide and three JmjC KDM inhibitors using a panel of SCLC cell lines representing all the SCLC transcription factor subtypes and found that SCLC responses to JmjC KDM inhibitors did not correlate with their responses to etoposide. Furthermore, I found that upon …
-
The role of the chromatin remodeller ISWI in the cellular response to hypoxia
… during the cellular response to hypoxia. The JmjC family of enzymes are capable of tri-methyl histone demethylation and require molecular oxygen to function making them putative oxygen sensors. Moreover, microarray array data within this thesis confirms that 10 of the JmjC demethylases are …
-
Roles of H2A.z in Fission Yeast Chromatin
… or repressed genes. Msc1 is one of the seven JmjC Domain Proteins (JDPs) in Fission Yeast. JDPs are known to function in chromatin and some act as histone demethylases. We found that Msc1 is a member of Swr1 Complex which is known to exchange histone H2A variant H2A.z in nucleosomes. We …
-
Identification and Characterisation of the Barley Row-Type Gene <i>VRS3 </i>
… identified <i>VRS3</i> to be a highly conserved JmjC histone demethylase, with two natural alleles within European cultivated barley. <i>VRS3</i> was further characterised as a potential means of improving grain uniformity within cultivated six-rowed barley, through phenotypic assessment of grain …
-
Molecular Mechanisms Underlying Aerobic Respiration and Heme Regulation in Yeast
… activity of Gis1 by heme. Gis1 belongs to the JmjC family of histone demethylases. Gis1 protein has two heme regulatory motifs (HRM). We show that the DNA binding zinc finger domain of Gis1 promotes the heme activation of its transcriptional activity, although heme does not affect Gis1 binding …