Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Japanese Encephalitis"”.
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Genotypic and Phenotypic Determinants of Japanese Encephalitis Virus Geographical Expansion
Japanese encephalitis virus (JEV) consists of at least four geographically and epidemiologically distinct genotypes (GI-IV). Genotypes II and IV have been isolated in tropical Asia only, and GI has recently replaced GIII as the dominant JEV genotype throughout Asia. Therefore, the objective of this …
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Usutu Virus: An Emerging Arbovirus Threat
… virus (CHIKV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), and West Nile virus (WNV) are major threats to global public health resulting in millions of infections and hundreds of thousands of deaths annually. The presence of these viruses and their increasing …
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Methods for the Genetic Stabilization of Reporter Flaviviruses and their Applications
… with Zika, yellow fever, dengue serotypes 1-4, Japanese encephalitis, and West Nile viruses. Notably, these viruses can be used to determine serum neutralization titers in less than twenty-four hours, whereas the traditional assay takes up to a week. The stabilization of flaviviruses bearing …
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Methods for the Genetic Stabilization of Reporter Flaviviruses and their Applications
… with Zika, yellow fever, dengue serotypes 1-4, Japanese encephalitis, and West Nile viruses. Notably, these viruses can be used to determine serum neutralization titers in less than twenty-four hours, whereas the traditional assay takes up to a week. The stabilization of flaviviruses bearing …
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The Structural Basis of Flaviviridae Interaction with Antibodies and Receptors
… responsible for a variety of diseases including encephalitis, hemorrhagic fever and hepatocellular carcinoma. The envelope: E) proteins that coat the outer surface of these viruses provide the molecular machinery that drives receptor interaction and membrane fusion. The assignment of biological …
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Cross-protection from St. Louis encephalitis virus and Usutu virus disease by human West Nile virus convalescent plasma in mice
West Nile virus (WNV), Saint Louis encephalitis virus (SLEV), and Usutu virus (USUV) are emerging mosquito-borne flaviviruses. These viruses are phylogenetically closely related and belong to the Japanese encephalitis serocomplex group. Similar to other flaviviruses, these viruses are enveloped, …
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Generation and Characterization of Flavivirus Receptor-Binding Domain Mutants and Chimeras
… diseases range from mild febrile infections to encephalitis and hemorrhagic fever. The molecular basis of the differences in disease presentation between genetically related viruses is uncertain, but potentially involves the putative receptor-binding domain of the envelope glycoprotein, domain …
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Population Structure of Yellow Fever Virus: Influence of Viral Diversity on Vaccine Attenuation
… alleles. Finally as confirmation, the Japanese encephalitis vaccine strain SA14-14-2 was compared to its wild-type parental strain SA14 by deep sequencing, revealing that loss of diversity for the vaccine was localized to regions of the genome previously thought to influence …
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Mechanistic analysis of the Zika virus translation-replication switch
… pathogens including Dengue virus (DENV) and Japanese encephalitis virus. Infection with ZIKV has been linked to congenital microcephaly as well as Guillain-Barré syndrome in infected adults. During infection, flavivirus replication is known to require genome circularisation, mediated by …
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Developing a Novel, Safe, and Effective Platform for Generating Flavivirus Vaccines
… Zika, yellow fever, dengue, West Nile, and Japanese encephalitis viruses) are arthropod-borne, globally distributed, and can cause a range of neurological or hemorrhagic diseases. The ongoing epidemics of flaviviral disease consistently demonstrate the need for new vaccines capable of …
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West Nile virus vaccination protects against Usutu virus disease in mice
… Usutu virus (USUV), West Nile virus (WNV), and Japanese encephalitis virus (JEV), are rapidly emerging, global pathogens. Though the number of people impacted by each virus varies, there have been thousands to millions of people infected. The focus of this thesis work centers around USUV and …
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PART I CRYSTAL STRUCTURE OF A DIMERIZATION DOMAIN OF DROSOPHILA CAPRIN. PART II CHARACTERIZATION OF TWO CAS13B CRISPR-CAS SYSTEMS FROM PORPHYROMONAS GINGIVALIS
… SH3 domain-binding protein 1 (G3BP1), and the Japanese encephalitis virus (JEV) core protein. We have determined the crystal structures of a fragment (residues 187-309) of Drosophila Melanogaster Caprin (dCaprin), which mediates homodimerization through a substantial interface created by a …