Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Janus kinase (JAK)"”.
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are potential sites of …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are potential sites of …
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Chemical Induced Hypoxia Differentially Affects Gene Expression in Human Neuronal Cells
… message. Western blot analysis showed the Janus kinase (JAK)/ Signal Transducers and Activators of Transcription (STAT) pathway was activated and an increase in STAT3 (P-STAT3) levels at was observed at 12 and 24 hour treatment. Heavy metal compounds such as cobalt chloride …
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Suppression of LPS-induced cytokines/chemokines production by CXCL1 siRNA
… data showed that the treatment of cells with a Janus kinase (JAK) inhibitor or CXCL1 siRNA#2 suppresses CXCL1 gene expression and reduces TNF-α production in response to LPS. SiRNA#2 also led to significant inhibition of LPS-induced pro-inflammatory chemokines, kinases, transcriptional factors, …
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Characterization of Jak, Stat, and Src Interactions In Head and Neck Squamous Cell Carcinoma
… of current treatments. Proteins in the Src/Jak/STAT pathway represent potential therapeutic targets, as this pathway is hyperactive in HNSCC and it has roles in cell migration, metastasis, proliferation, survival, and angiogenesis. During short-term Src inhibition, Janus kinase (Jak) 2, and …
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Combinatorial strategy to generate antibody-cytokine fusions with "activity-on-demand" for cancer therapy
… inhibitors are rapidly cleared from circulation. Janus kinase (JAK) inhibitors may be ideally suited for this purpose, as JAK proteins are key signaling mediators for several payloads, including IL12 and IL2. In the first part of this thesis, the Intra-Cork technology has been validated on …
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Analysis of PINK1/Parkin-related mitochondrial quality control in Drosophila
… ligase, and PINK1, a mitochondrially targeted kinase, have been shown to play key roles in this mitophagy. However, little is known about their impact on basal mitophagy in vivo. Moreover, while the consequences of mitophagy defects and the mechanisms that lead to neuronal cell death are …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… of a pro-survival mitogen activated protein kinase kinase (MEK)1/2/ extracellular signal regulated-kinase (ERK)1/2 cascade which functions in healthy CGNs to promote the degradation of the pro-apoptotic Bcl-2 homology-3 domain (BH3)-only protein Bim while also repressing a pro-apoptotic Janus …
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Transcriptional regulation of human mu-opioid receptor gene: functional characterization of activating and inhibitory transcription factors
… 2004). These include: phosphatidylinositol 3-kinase, mitogen-activated protein kinase (Vincent and Feldman 2002; Di Toro et al. 2005) and members of the Janus kinase (JAK)/STAT3 signalling pathway (Zong et al. 2000; Yadav et al. 2005). REST plays a complex role in neuronal cells by …