NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 26 for “"Janus kinase"”.

  1. Identifizierung und Charakterisierung von Interaktionspartnern der Janus-Kinase Hopscotch in Drosophila melanogaster

    Bogin, JochenUniversität Heidelberg

    … Rezeptor-assoziierten Tyrosin-spezifi-schen Janus-Kinasen (Jaks) und Transkriptionsfaktoren, den �Signal transducers and activators of transcrip-tion� (Stats) zusammensetzt. Jaks nehmen eine zentrale Stellung in diesem System ein: zum einen interagieren sie direkt mit membrangebundenen …

    heid-diss Repository record

  2. ANAGRELIDE E FATTORE DI CRESCITA FIBROBLASTICO-2 (FGF-2) NELLA TROMBOCITEMIA ESSENZIALE

    FERLITO, CARMENUniversità degli studi di Catania2012

    … interleukin (IL)-6 in essential thrombocythemia, janus kinase V617F mutation and inflammatory interleukins in patients with essential thrombocythemia,

    catania Repository record

  3. Das gp130-Zytokin Novel Neurotrophin-1/B Cell Stimulating Factor-3 stimuliert die POMC-Genexpression und ACTH-Sekretion der kortikotrophen Zellen über einen Jak (Janus Kinase)- und STAT (Signal Transducer and Activator of Transcription)-abhängigen Mechanismus

    Isele, NicolaLudwig-Maximilians-Universität

    lmu-germany Repository record

  4. Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries

    King, Jonathan ChanDivision of Cardiology2011

    … but the mechanisms involved remain unclear. Janus kinase/Signal transducer and activator of transcription 3 (JAK/STAT-3) form part of a recently discovered powerful prosurvival path termed as the Survivor Activating Factor Enhancement (SAFE) pathway. The SAFE pathway plays a critical role in …

    cape-town Repository record

  5. Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion

    Chan, Li-Chuan, <p>https://orcid.org/0000-0002-2665-637X</p>2020

    … Here we show interleukin (IL)-6-activated Janus kinase 1 (JAK1) phosphorylates programmed death-ligand 1 (PD-L1)-Tyr112, leading to the recruitment of endoplasmic reticulum (ER)-associated N-glycosyltransferase, STT3A, which catalyzes the glycosylation of PD-L1, contributing to its …

    uthsc Repository record

  6. The Role of Prolactin in the Cellular Response to DNA Damaging Agents

    Karayazi Atici, OdulGraduate Studies2015

    … protein-90 (HSP90), Hsp90alpha, is a prolactin-Janus kinase-2 (Jak2)-signal transducer and activator of transcription-5 (Stat5) regulated gene in breast cancer cells. We have now observed that prolactin increased the viability of breast cancer cells to DNA damaging chemotherapeutics, and Hsp90 …

    calgary Repository record

  7. Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function

    Moshapa, Florah T.University of Bradford2021

    … of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are potential sites of …

    bradford Repository record

  8. Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function

    Moshapa, Florah T.University of Bradford2021

    … of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are potential sites of …

    bradford Repository record

  9. Investigation of novel topical therapeutics for chronic rhinosinusitis

    Hale, Samuel James MitchellResearchSpace@Auckland2025

    … Zoono GermFree24 and Nasodine; tofacitinib, a Janus kinase inhibitor, for management of the dysregulated immune response; and tetracaine with oxymetazoline to facilitate postoperative debridement and optimise surgical outcomes. All antimicrobials tested had varying degrees of efficacy against …

    auckland-ms Repository record

  10. Overcoming Resistance to CDK4/6-targeted Therapy Using JAK2/STAT3 Inhibitor in Triple-Negative Breast Cancer

    Zhuang, Chuling, <p>0009-0007-0859-9491</p>2026

    … of recurrence and metastasis. Cyclin-dependent kinase 4 and 6 (CDK4/6) are major cell cycle regulators that control G1 to S phase transition and aberrant hyperactivation of the CDK4/6 pathway results in uncontrolled cell proliferation. Although three CDK4/6 inhibitors (CDK4/6is) have achieved …

    uthsc Repository record

  11. Chemical Induced Hypoxia Differentially Affects Gene Expression in Human Neuronal Cells

    Pavlichko, Natasha V.2014

    … message. Western blot analysis showed the Janus kinase (JAK)/ Signal Transducers and Activators of Transcription (STAT) pathway was activated and an increase in STAT3 (P-STAT3) levels at was observed at 12 and 24 hour treatment. Heavy metal compounds such as cobalt chloride …

    shu-thes Repository record

  12. A Molecular Cytogenetic Profile of the Chronic Myeloproliferative Disorders

    Vaughan, Beverley RebeccaDe Montfort University2007

    … karyotpyes, focusing on the region containing Janus Kinase 2 Gene (JAK2) at 9p24.1. In this ongoing study 18% of patients have been shown to carry a relative loss in this region. The pathogenomic significance of imbalances involving 9p remains unclear. It may however, represent an acquired …

    de-montfort Repository record

  13. Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation

    Bulut, Gamze Betul2016

    … progenitor cells. Epo binding to EpoR activates Janus kinase 2 (JAK2), which phosphorylates cytoplasmic tyrosines of the EpoR. Signaling proteins bind these phosphotyrosines through SH2 domains, leading to the survival and proliferation of erythroid progenitor cells and the differentiation of …

    utswmed Repository record

  14. Suppression of LPS-induced cytokines/chemokines production by CXCL1 siRNA

    Elgreu , Thuraya Nuri2025

    … data showed that the treatment of cells with a Janus kinase (JAK) inhibitor or CXCL1 siRNA#2 suppresses CXCL1 gene expression and reduces TNF-α production in response to LPS. SiRNA#2 also led to significant inhibition of LPS-induced pro-inflammatory chemokines, kinases, transcriptional factors, …

    bu Repository record

  15. Supplementing Bovine Embryo Culture Media to Improve the Production and Quality of In Vitro Produced Bovine Embryos

    Wooldridge, Lydia KatherineVirginia Tech2020

    … of STAT3 by IL6 could be blocked with a chemical Janus kinase 2 (JAK2) inhibitor (AZD1480). JAK2 inhibition from day 5 to 8 resulted in blastocyst ICMs with fewer than 10% the normal cell number, regardless of IL6 supplementation. This indicates that STAT3 is critical for bovine ICM development. …

    vt Repository record

  16. The conservation of suppressor of Cytokine Signalling 3 in mediating intestinal homeostasis

    Smith, Emily, Rigby, Rachael, Broughton, SusanLancaster University2016

    … 3 (SOCS3) is produced upon activation of the Janus kinase/Signal transducer and activator of transcription (Jak/Stat) pathway and this is an inducer of negative feedback inhibition and is implicated in regulation of intestinal homeostasis, with SOCS3 dysregulation reported in intestinal …

    lancaster Repository record

  17. Characterization of Jak, Stat, and Src Interactions In Head and Neck Squamous Cell Carcinoma

    Jaseja, Reshma2014

    … angiogenesis. During short-term Src inhibition, Janus kinase (Jak) 2, and signal transducer and activator of transcription (STAT) 3 and STAT5 are dephosphorylated and inactivated. Following sustained Src inhibition, STAT5 remains inactive, but Jak2 and STAT3 are reactivated following their early …

    uthsc Repository record

  18. Amphiphilic Cell-Penetrating Hybrid Cyclic-Linear Peptides as a Drug Delivery System

    Mozaffari, Saghar2022

    … Silencing of kinesin spindle protein (KSP) and Janus kinase 2 (JAK2) was evaluated in MDA-MB-231 cells in the presence of the peptides. The addition of DOPE significantly enhanced the silencing efficiency for all selected peptides.</p> <p>A chemotherapeutic drug, doxorubicin (Dox) was covalently …

    chapman Repository record

  19. Combinatorial strategy to generate antibody-cytokine fusions with "activity-on-demand" for cancer therapy

    Rotta, GiuliaUniversità degli studi di Trento2024

    … inhibitors are rapidly cleared from circulation. Janus kinase (JAK) inhibitors may be ideally suited for this purpose, as JAK proteins are key signaling mediators for several payloads, including IL12 and IL2. In the first part of this thesis, the Intra-Cork technology has been validated on …

    trento Repository record

  20. Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling

    Fleegel, JonathanCreighton University2026

    … This dissertation tests the hypothesis that Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, and particularly JAK2-dependent signaling, contributes to cochlear resilience during aminoglycoside ototoxic stress. To nominate candidate pathways, early …

    creighton Repository record

Page 1 of 2