Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Jak1"”.
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The role of JAK1 and JAK3 in CD8<sup>+</sup> effector T cells
… was to explore the role of the tyrosine kinases JAK1 and JAK3 in cytokine signalling, focusing on interleukin-2 signalling in CD8<sup>+</sup> effector T lymphocytes. Initial experiments compared the effects of the pan JAK1/JAK3 inhibitor tofacitinib, the selective JAK1 inhibitor GSK186, and the …
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Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
… interleukin (IL)-6-activated Janus kinase 1 (JAK1) phosphorylates programmed death-ligand 1 (PD-L1)-Tyr112, leading to the recruitment of endoplasmic reticulum (ER)-associated N-glycosyltransferase, STT3A, which catalyzes the glycosylation of PD-L1, contributing to its stability. A positive …
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Identification of the molecular pathways that mediate cytokine induced immunopathology of the gut epithelium
… screen identified the Janus kinases (JAKs) JAK1 and JAK2 as the major kinases required for IFN-γ + TNF-α dependent synergistic cell death. While TNF receptor-1 (TNFR1) was also required, there was no direct dependency of cell death on TNFR1-downstream canonical apoptotic and necroptotic …
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Identification of the presence and activity of the JAK-STAT pathway in canine solid tumors
… was performed to evaluate protein levels of JAK1, phospho-JAK1, JAK2, phospho-JAK2, STAT3, and phospho-STAT3. Signalment, treatment information, and survival information was obtained from the medical record for each case. Results: Tumor samples were scored for percent positive neoplastic …
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Expression und Aufreinigung von intrazellulären Anteilen des Interleukin-4-Rezeptors als GST-Fusionsproteine und Messung von Protein-Protein-Wechselwirkungen
… Für GST-E1 wurde eine Wechselwirkung mit Jak1 nachgewiesen, die dem bisherigen Kenntnisstand entspricht; für GST-ginP5D4 hingegen konnte eine Wechselwirkung mit Jak3 nicht gezeigt werden. Beide Proteine sind in der Lage, STAT5 zu präzipitieren; diese Bindung erscheint unabhängig von der …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
… alone. In adult mouse models, systemic dual JAK1/2 inhibition with momelotinib worsened hearing loss and cochlear damage in an inflammatory kanamycin paradigm. Subsequent kinase specific pharmacologic studies refined this finding: systemic JAK1-biased inhibition with upadacitinib or …
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Role of JAK3 in Myogenic Differentiation
… (MRFs) family and many signaling pathways. The JAK1 and JAK2 pathways are known to each have different effects on myoblast proliferation and differentiation; however, the role of JAK3 in myoblast differentiation remains unclear. In this study, we investigated the effect of JAK3 inhibition on …
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The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia
… the phosphorylation of STAT1/3 as well as JAK1/2 in microglia activated with gangliosides, LPS, or IFN-γ. Curcumin inhibits the expression of inflammation-associated genes, including ICAM-1 and MCP-1, whose promoters contain STAT-binding elements. To test the inhibitory mechanism of …
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Determinants of systemic treatment response in atopic dermatitis
… and translational study examined selective JAK1 inhibition with abrocitinib. Rapid clinical improvement was accompanied by restoration of barrier integrity, downregulation of inflammatory proteins, and normalization of skin physiology and microbial diversity.
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Hyperinsulinemia and Hyperglycemia Contribute to Diabetic Complications Through Cytokine Resistance and Altered Macrophage Function
… that has a negative effect on the ability of JAK1 to tyrosine phosphorylate IRS-1, (2) with conditions mimicking hyperinsulinemia and hyperglycemia, as well as in an animal model of type 2 DM, the ability of IL-4 to stimulate PI3-kinase activity is reduced through a mTOR-dependent mechanism, …
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Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases
… necroptosis and was regulated via a caspase-8-JAK1/2-STAT1 pathway with STAT1 activation playing a significant role. Our results show that TRAIL is a TNF-α like molecule from the TNF superfamily and is a potential target for the treatment of IBD. The Casp-8/JAK1/2-STAT1 pathway plays a major …
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New Target Genes For Tumor Suppressors P53 and P73 In Regenerating Liver
… expression after PH. Four of these genes, Foxo3, Jak1, Pea15, and Tuba1 have p53 response elements (p53REs), identified in silico within the upstream regulatory region. Forkhead transcription factor Foxo3 is the most responsive gene among transcription factors with altered expression during …
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Gangliosides와 oxidized low density lipoprotein (oxLDL) 에 의한 신경교세포의 활성조절 및 그 기전에 대한 연구
… Induce Phosphorylation and Activation of JAK1 and JAK2 25 4. Gangliosides Stimulate STAT-responsive Inflammatory Gene Expression 28 5. AG490 Reduces Gangliosides-induced Release of NO 28 6. ERK Activity Appears to be Regulated by JAK Activation 30 7. Sialic Acid Residues Are Important for …
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Molekulare Mechanismen der antiinflammatorischen und immunsuppressiven Effekte von Interleukin-10
… eingeleitet. Nachfolgend werden die Januskinasen Jak1 und Tyk2 und die Transkriptionsfaktoren Stat3 und Stat1 durch Phosphorylierung aktiviert. Die Folgen dieser Kaskade sind die Transkription verschiedener Gene, deren Endprodukte die Wirkung von IL-10 vermitteln. Da die Transkriptionsfaktoren …
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Developing druggable in vitro models for investigating itch in atopic dermatitis
… skin environment. It was found that TRPA1 and JAK1/2 inhibition reduced iPSCSN responses to the pruritogens thymic stromal lymphopoietin and interleukin-31, thus highlighting TRPA1 as a therapeutic target. In addition, other iPSCSN differentiation methods were explored and yielded functional …
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Investigation of the role of CUZD1-STAT5 signaling in mammary gland development and breast cancer
… with a multi-protein complex containing JAK1/JAK2 and STAT5. Elevated expression of CUZD1 in HC11 cells stimulated phosphorylation and nuclear translocation of STAT5. Chromatin immunoprecipitation experiments indicated that STAT5 and CUZD1 co-occupy the same regulatory region of the Ereg …
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Combinatorial strategy to generate antibody-cytokine fusions with "activity-on-demand" for cancer therapy
… technology on F8-IL2 using the approved JAK1-selective inhibitor Upadacitinib. One of the major life-threatening toxicities of IL2-based products is vascular leak syndrome (VLS), leading to generalized edema and organ failure, which could be fully recapitulated in our in vivo model. …
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The role of the type-I interferon response in the aggregation of tau protein
… in vivo. Both an α-IFNAR blocking antibody and a JAK1/JAK2 inhibitor, baricitinib, were able to prevent the IFN-I driven increase in seeded tau aggregation in neural cultures. Pilot studies of baricitinib administration to P301S-tau mice showed that whilst intraperitoneal administration was well …
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Exploring the effect of peri-operative inflammation on systemic and local breast cancer biomarkers
… (NAT) and tumour tissue samples, IL6, Leptin, JAK1, CD38, FABP4 and Adiponectin gene expression were significantly higher in NAT compared to matched tumour samples. Pre-operatively the mean cfDNA concentration was 3.82ng/μL (SEM = 0.74). This increased significantly early post-op in keeping …