Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Jagged-1"”.
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Novel Role of ErbB-2 in Inhibition of Jagged-1-Mediated Trans-Activation of Notch in Breast Cancer
… receptor is overexpressed with its ligand Jagged-1 in breast cancers with the poorest overall survival. We showed that ErbB-2 inhibition activates Notch-1 which</p><p>results in a compensatory increase in Notch-1-mediated proliferation. However, we do not yet know the mechanism by which …
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Engineered microenvironments for studying liver progenitor differentiation
… we demonstrated a cooperative influence of Jagged-1 and TGFβ1 on cholangiocytic differentiation. We established ECM-specific effects using cellular microarrays consisting of 32 distinct combinations of collagen I, collagen III, collagen IV, fibronectin, and laminin. In addition, we …
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The Role of Mesenchymal Stromal Cells in Inflammation and Treatment of Pulmonary Fibrosis
… of Treg cells was shown to be dependent on Jagged 1 signalling. MSC inhibition of DC maturation and antigen presentation was shown to also involve Jagged 1 however IL-6 signalling is also necessary. MSC inhibition of DC maturation resulted in a semi mature or “tolerogenic” DC, expressing …
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Notch-1 Activates Nf-Кb Activity in Cervical Cancer and Estrogen Receptor Negative Breast Cancer
… dependent genes. Notch activation mediated by Jagged-1 or EDTA activates Akt, which in turn activates the IKK complex. Notch activation mediated by Jagged-1 also induces NF-КB subunits, Pol II and IKKα recruitment to the NF-КB dependent gene promoters. Inhibiting Akt pharmacologically or …
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Autonomous and non-autonomous regulation of chromatin structure during cellular senescence
… or cancer cells that express the NOTCH ligand jagged-1 can drive similar chromatin structural changes in adjacent cells in a cell-cell contact dependent manner. In addition, using a highly optimised chromatin immunoprecipitation (ChIP-seq) protocol and the proximity ligation assay ‘Hi-C’, we …
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DLL4 and JAG1 in the Glioblastoma Response to Temozolomide Chemotherapy
… of the Notch ligands, Delta-like 4 (DLL4) and Jagged-1 (JAG1) on tumour resistance to TMZ and GCSCs. Methods: U87 and U251 glioblastoma cells were transduced with empty vector-, DLL4, and JAG1-encoded retroviruses. Cells were cultured under 2D, 3D, and CSC culture conditions and response to …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
… primary CCRCC samples revealed that Notch-1 and Jagged-1 were expressed at significantly higher levels compared to normal kidney tissue samples. Finally, we found that inhibition of Notch signaling decreased the migratory potential of CCRCC cells. This effect might be linked to a cross-talk …
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The Role of Notch Signaling in the Pathogenesis of Acute Promyelocytic Leukemia
… that human APL overexpresses the Notch ligand Jagged-1: JAG1) compared to other AML and normal promyelocytes. Unlike many APL signature genes, overexpression of JAG1 is also found in human APL cell lines and in murine APL. We hypothesized that Notch signaling, which has known roles in …