Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Jag1"”.
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DLL4 and JAG1 in the Glioblastoma Response to Temozolomide Chemotherapy
… Notch ligands, Delta-like 4 (DLL4) and Jagged-1 (JAG1) on tumour resistance to TMZ and GCSCs. Methods: U87 and U251 glioblastoma cells were transduced with empty vector-, DLL4, and JAG1-encoded retroviruses. Cells were cultured under 2D, 3D, and CSC culture conditions and response to single …
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Regulation of Notch Ligands Dll1 and Jag1 by Pax6 during cortical development
… between Pax6 and Notch ligands Dll1 and Jag1 during cortical development. Analysis by flow cytometry and double labelling analysis of both gene and protein expression has provided insight into the relationship between Pax6 and Dll1 in progenitor cell subpopulations during cortical …
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
… models. In the clinic, upregulation of JAG1 gene expression was observed in recurrent high-grade glioma patients treated with CAN-3110. Since JAG1 is expressed on both glioma cells and tumor-associated macrophages (TAMs), and its expression correlated with a worse prognosis, we …
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The Role of Notch Signaling in the Pathogenesis of Acute Promyelocytic Leukemia
… APL overexpresses the Notch ligand Jagged-1: JAG1) compared to other AML and normal promyelocytes. Unlike many APL signature genes, overexpression of JAG1 is also found in human APL cell lines and in murine APL. We hypothesized that Notch signaling, which has known roles in proliferation and …
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Molecular determinants of mammary differentiation and breast cancer progression
… required for basal fate commitment to activate JAG1 expression, which indirectly stimulates luminal NOTCH1 signaling to drive lobulogenesis. Collectively, these data provide insight into key molecular regulators of breast cancer progression and mammary differentiation.
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
… with ECM proteins. The Notch ligands Jag1 and Dll1 were further found to found play distinct cell-intrinsic and cell-extrinsic roles in differentiation towards a biliary epithelial cell fate. Parallel TFM measurements in arrayed microenvironments indicated that progenitor cell …
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Engineering soft matter for cell biology from a biophysical point of view
… results, I hypothesise that proliferation of JAG1 expressing A549 cancer cells can be positively modulated through the NOTCH-mediated signalling of the stromal cells, such as IMR90. This thesis represents an interdisciplinary approach to address the challenges of biological fundamentals and …
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The hybrid epithelial/mesenchymal phenotype and its implications in cancer metastasis
… and identify novel targets – OVOL1/2, GRHL2 and JAG1 – to curb metastatic load.
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
… endothelial cells (HDLECs), whereas Jagged1 (Jag1) was not. In HDLECs, Notch signaling is activated in response to Vascular Endothelial Growth Factor (VEGF) or Vascular Endothelial Growth Factor-C (VEGF-C) stimulation. In vitro assays demonstrated that Notch activation inhibits HDLEC …
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Integrated approaches to elucidate the genetic architecture of congenital heart defects
… variants. Both of NOTCH1 and its ligand JAG1 harbor two additional de novo mutations (two stop gains in NOTCH1 and one missense and a splice donor in JAG1). The analysis showed a strongly significant over-representation of de novo loss-of-function variants in NOTCH1 (P=3.8 ×10-9). …
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Development of Vessels, Airways and Cartilage Rings: The role of T-box genes
… and signaling molecules Bmp2, Bmp7, Notch2, Jag1 and Wnt2In addition, we show that the canonical Wnt signaling pathway contributes to the vessel-forming potential of the allantois. Ex vivo, the Tbx4 mutant phenotype can be rescued using agonists of the Wnt signaling pathway and an inhibitor …
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ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
… significantly augmented the expression of JAG1 in the reactive astrocytes, which in turn activated Notch signaling pathway of cancer stem-like cells (CSCs) upon direct interaction. We also found that the activated Notch signaling in CSCs up-regulated Sox2 followed by promoting self-renewal …
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Studio del pathway della Displasia Ectodermica Anidrotica (EDA)
… changes for 3 selected genes, Tbx1, Bmp7, and Jag1, both in primary keratinocytes and in Wild-type and Tabby whole skin, by Q-PCR and Western blotting analyses. Thus, this study detected novel candidate pathways downstream of EDA. In the second part of the research project, plasmid constructs …
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Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …