Global ETD Search
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Showing 1 to 2 of 2 for “"Jab1/CSN5"”.
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Antiapoptotische Wirkungen des Makrophagen-migrationsinhibierenden Faktors (MIF) auf das Tumorsuppressorprotein p53 bei der ROS-induzierten Apoptose
… through protein-protein interactions (MIF-CSN5/JAB1 (CSN5/JAB1-monomer or MIF-mini-CSN5/JAB1-complex)). Although a physical interaction of MIF and p53 was not detected, a competition between MIF and p53 for the common binding partner CSN5/JAB1, which was observed during …
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Jab1 Negatively Regulates Pten and Promotes Resistance to Trastuzumab In Her2-Positive Breast Cancer
… reduced expression of PTEN protein.</p> <p>Jab1 is over-expressed in 50% of primary cancers and 90% of metastatic tumors. Our lab previously showed that depletion of Jab1 in combination with trastuzumab treatment up-regulated PTEN in mouse xenografts refractory to trastuzumab. PTEN was not …