Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"JQ1"”.
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Clonal deconvolution of transcriptomic signatures and their spatial organisation in a mouse model of breast cancer
… the clonal response to the epigenetic regulator JQ1 which revealed intrinsic signatures that primed clones to JQ1 sensitivity. We observed JQ1-dependent depletion of CD8+ cytotoxic T-cells and suggest that this drives changes in clonal distribution. Finally, we are working on developing a high …
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Small-molecule inhibition of general transcriptional regulators in cancer
… - the CDK7-inhibitor THZ1 and the BRD4-inhibitor JQ1 - and suggest a model describing the molecular basis of the synergistic effects I observed. My research provides insight into the effects of these inhibitors of general transcriptional regulators on tumor cell behavior and gene expression …
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Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
… to normal tissue. Meanwhile, BET inhibitor JQ1 inhibited multiple gastric cancer cell proliferation by inducing BRD4-dependent cellular senescence. Depletion of BRD4, but not other BET proteins, recapitulated JQ1-induced cellular senescence with increased cellular SA--Galactose activity and …
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Investigating the Mechanisms of Resistance to Dual PI3K/MTOR Inhibitor in PIK3CA Mutant Basal Like Bladder Cancer
… we observed bromodomain inhibition by JQ1 to be the most effective strategy to re-sensitize resistant cells to PI3K targeted therapy. Overall, this project provides a predictive paradigm of response to PI3K targeted inhibition in PIK3CA mutant MIBC and sets the stage for future rational …
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Mechanistic and Therapeutic Insights for Epigenetic Regulation in Cancer Development
… inhibition with small molecule inhibitor JQ1. Indeed, genetic and pharmacological inhibition of BRD4 profoundly suppresses both growth and tumorigenesis of MPNSTs. Mechanistically, we uncovered that BET bromodomain inhibition leads to engagement of the ER stress/UPR pathway, and apoptosis …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… identify a small molecule inhibitor of BRD4, JQ1, which can not only prevent but also reverse the myofibroblast phenotype in cells taken from hypertrophic scars of burn patients. In conclusion, my work suggests that fibroblast-RelA is not necessary for myofibroblast transdifferentiation but it …
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Engineering translational multi-therapeutic targeted delivery vehicles for disease management
… inhibitor) in a folate-targeted liposome; (+)-JQ1-temozolomide in a transferrin-targeted liposome) and disease targets (non-small cell lung cancer; brain stem gliomas). Using both LbL and liposomal manufacture, work detailed herein represents a broad skill set for engineering and manufacturing …