Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"JNK1/2"”.
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Biochemical effects of organophosphorous compounds on cultured rat and human cardiomyocyte-like cells
… H9c2 cells. PSP triggered the activation of JNK1/2, suggesting a role for this pro-apoptotic protein kinase in PSP-induced cell death, which was attenuated by the JNK1/2 inhibitor SP 600125, confirming the role of JNK1/2 activation in PSP-induced cytotoxicity. Dansylated PSP was used to …
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Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell
… pathways were also examined. Cytokines activated JNK1/2 and p38 MAPK kinases. They also increased CHOP [C/EBP homologous protein] expression, a marker for endoplasmic reticulum stress, caused caspase-3 activation and FTase and GGTase degradation which leads to defective activation of key …
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Mechanisms of regulation of islet function by nadph oxidase
… stress, activation of stress-activated kinases [JNK1/2] and mitochondrial abnormalities underlies pancreatic â-cell dysfunction[s] during diabetes. Additional studies are needed to understand the precise regulatory roles for Tiam1-Rac1-Nox-ROS-JNK1/2 signaling to develop therapeutic strategies in …
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UNDERSTANDING HOW MAP KINASES INFLUENCE ENDOTHELIAL NITRIC-OXIDE SYNTHASE ACTIVITY
… both sites. Literature reports showed that JNK1/2 activation does not alter eNOS activity and prior work in our lab showed that ERK phosphorylation negativity affects NO output. This thesis presents <em>in vitro </em>results comparing the direct impact of each kinase on eNOS activity using …
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Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
… against the key kinases, it was shown that P38, JNK1/2, ERK5 played important roles in cytokine induced cell death in bovine and human cartilage, while inhibition of JNK1/2 and ERK5 had the anti-catabolic effect of reducing GAG loss from cartilage matrix. In addition, JNK inhibition sensitized …
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Up-regulation of junctophilin-2 prevents ER stress and apoptosis in hypoxia/reoxygenation-stimulated H9c2 cells
Ischemic heart disease is the leading cause of death, and reperfusion which can restore blood flow is the primary therapy. However, reperfusion can induce further damage to cardiomyocytes, a condition described as ischemia-reperfusion (I/R) injury. I/R is now recognized as a combination determining …