Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"JNK signaling"”.
-
Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia
… activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process. However, c-jun expression has not been investigated in acute myeloid leukemia (AML) cells containing the most common chromosomal translocations. t(8;21) is one of …
-
The <i>Drosophila</i> T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival
… receptor (InR) and the c-Jun-N-terminal kinase (JNK) signaling pathways to regulate interommatidial bristle (IOB) formation. Previous studies have identified <em>mid</em>’s role in cell fate specification of sensory organ precursor cells in conjunction with the Notch-Delta signaling pathway (Das …
-
The function of chromatin regulators during patterning and growth in Drosophila wing disc regeneration
… timing, and is required for the expression of JNK signaling targets and the growth promoter Myc. By contrast, the BAP complex is required for ensuring proper patterning and cell fate by stabilizing the expression of the posterior gene engrailed. Thus, both SWI/SNF complexes are essential for …
-
Elucidating binding modes of zuonin A enantiomers to JNK1 via in silico methods
Aberrant JNK signaling can result in two main forms of disease in humans: 1) neurological, coronary, hepatobiliary, and respiratory diseases and 2) autoimmune, inflammatory, and cancer conditions. Enantiomers of the lignan zuonin A, (-)-zuonin A and (+)-zuonin A, have been shown to bind to JNK …
-
The guardians of cell fate: protective mechanisms that ensure proper cell fate and patterning during imaginal disc regeneration in drosophila
… fate changes that are induced by the powerful JNK signaling cascade at the wound misregulating the expression of engrailed. The other chapter will detail the identification of the pioneer transcription factor Zelda as being upstream of taranis expression during regeneration. Zelda is found to …
-
Role of PI3K and MAPK in Regulating the IL-10-Induced Temporal Transcriptional Program in LPS-Triggered Macrophages
… in the presence of concurrent TLR signaling, and are thus termed IL-10 super-induced genes. TNIP3 is part of a larger cohort of IL-10 super-induced genes, and the synergy for these genes occurs at a transcriptional level, not due to mRNA stabilization. Furthermore, these IL-10 …
-
Transcriptional Regulation of Profilin Is Required For Drosophila Larval Wound Closure
… In Drosophila larvae, wound closure requires two signaling pathways (the Jun N-terminal kinase (JNK) pathway and the Pvr receptor tyrosine kinase signaling pathway) and regulation of the actin cytoskeleton. In this and other systems, it remains unclear how the signaling pathways that initiate …
-
ROS regulation of axonal mitochondrial transport
… these effects, we examined Ca2+ levels and the JNK (c-Jun N-terminal Kinase) pathway, which have been shown to regulate mitochondrial transport and general fast axonal transport, respectively. We found that elevated ROS increased Ca 2+levels, and that the Ca2+ chelator EGTA rescued ROS-induced …
-
The Role of Traf6 Phosphorylation In Src/Traf6-Mediated Ikk, Jnk, Akt Activation and Tumorigenesis
… it mediates activation of IKK/NF-κB and JNK signaling in response to engagement of toll-like receptor 4 (TLR4), interleukin-1 receptor (IL-1R), and receptor activator of NF-κB (RANK) to their cognate ligands, including lipopolysaccharide (LPS), IL-1, and RANK ligand (RANKL). Recently, …
-
Regulation of Protein Degradation by ADP-Ribosylation
… poly-ADP-ribosylation, and the activation of JNK signaling with age. Furthermore, I demonstrated that the ubcD1 ubiquitin-conjugating enzyme enhances the ubiquitin ligase activity of Iduna. Finally, I proposed a model by which poly-ADP-ribosylation brings together Tankyrase, target proteins, …
-
Oncogenic Signaling Pathways Activated by Lysophosphatidic Acid (LPA) in Ovarian Carcinoma
… To gain further insight into the oncogenic signaling response stimulated by LPA, activation of the mitogen activated protein kinase (MAPK) modules was determined. Using a series of immunoblot analyses and kinase assays, LPA was found to stimulate ERK as well as JNK modules. To investigate …
-
Targeting chromosomal instability: screening and characterization of CIN killers.
… Genes identified include those involved in JNK signaling pathways, mitotic cytoskeletal regulation and metabolic pathways. This screen demonstrates that it is feasible to selectively kill cells with CIN induced by spindle checkpoint defects. It has identified candidates that are currently …
-
The role of purinergic receptors in the modulation of JNK signalling endothelial and cancer cells
… as atherosclerosis.1,2 Within the MAPK family, JNK (c-Jun NH2-terminal kinase) is strongly activated by pro-inflammatory cytokines, including tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β).3,4 Thus, this project examined the potential for purinergic and cytokine receptors to …
-
New insights into a complex host-pathogen interaction: mechanisms of Helicobacter pylori activation of NF-κB
… define the bacterial proteins and the cellular signaling molecules involved in H. pylori-induced NF-κB activation. The H. pylori virulence factor CagA, encoded by the cagPAI, is injected into host cells via a type 4 secretion system, where it interacts with a number of different signaling …
-
Fatty Acid Regulation of NLRP3 Inflammasome Activity
… exposure leads to activation of the MAP kinase JNK in the cytosol of macrophages and interference with JNK signaling blocks PA-induced NLRP3 activation. While SFAs activate the NLRP3 inflammasome, unsaturated fatty acids such as arachidonic acid (AA) inhibit NLRP3 activation. AA counteracts the …
-
C-Jun N-Terminal Kinases Regulate Adenovirus-Mediated Autophagy and Antigen Presentation
… phosphorylation of c-Jun N-terminal kinases (JNK) that was essential for autophagy. Adenoviral replication within the host cell elicited JNK pathway activation leading to B cell lymphoma-2 (Bcl-2) phosphorylation. JNK-dependent Bcl-2 phosphorylation stimulated the dissociation of Bcl-2/beclin …
-
The Syndecan-1 Paradox in HSV-1 Infection and Pathogenesis
… as a key driver of this process through the JNK-EGR-1-HPSE axis, leading to glycocalyx remodeling and enhanced viral spread. Importantly, pharmacological inhibition of JNK signaling significantly reduces SDC1 shedding, limits viral dissemination, preserves epithelial integrity, and attenuates …
-
CAMK-II: AN INTEGRAL PROTEIN IN CELL MIGRATION
… been identified as an evolutionarily conserved signaling pathway, regulating C&E cell movements during vertebrate gastrulation. With the absence of the non-canonical Wnts (ncWnts), Wnt5 and Wnt11, during zebrafish development leading to a shorter and broader body axis with defects in elongation …
-
Costimulatory function of CD44
… TCR and a costimulatory molecule. However, the signaling cascade of costimulatory molecules has remained elusive. Here, I provide evidence that CD44 supports proliferation as well as apoptosis mainly, if not exclusively, by enhancing signal transduction via the TCR/CD3 complex. Blockade of CD44 …
-
Expression And Regulation Of Map Kinase Phosphatases 1 And 2 In Breast Cancer Tamoxifen Sensitivity
… of Philosophy</p> <p> The deregulation of cell signaling is a very important component in the development and progression of cancer. One group of signaling molecules that has been implicated in these processes is the Mitogen-Activated Protein Kinase (MAPK) family which consists of three major …
Page 1 of 2