Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 236 for “"JNK"”.
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Regulation of ERK1/2 and SAPK/JNK Phosphorylation by Histamine
… in allergic disease and asthma and SAPK/JNK and ERK1/2 are involved in certain aspects of allergic inflammation such as TH2 differentiation and proliferation and apoptosis. This study was designed to investigate the effects of histamine on ERK1/2 and SAPK/JNK phosphorylation in …
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JNK regulates Fas receptor mediated apoptosis in prostate cancer cell lines
… tumour from which the cell lines were isolated. JNK, a stress-activated protein kinase, has been implicated both with increased survival and increased apoptosis in prostate cancer. Elevated endogenous JNK activity has been demonstrated to correlate with prostate cancer progression. It has been …
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A DLK And JNK Dependent Axon Self-Destruction Program Promotes Wallerian Degeneration
… axons in Drosophila and mice, and its target JNK promotes degeneration locally in axons as they commit to degenerate. This pathway also promotes degeneration after chemotherapy exposure, and thus may be a component of a general axon self-destruction program.
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The Role of Traf6 Phosphorylation In Src/Traf6-Mediated Ikk, Jnk, Akt Activation and Tumorigenesis
… it mediates activation of IKK/NF-κB and JNK signaling in response to engagement of toll-like receptor 4 (TLR4), interleukin-1 receptor (IL-1R), and receptor activator of NF-κB (RANK) to their cognate ligands, including lipopolysaccharide (LPS), IL-1, and RANK ligand (RANKL). Recently, …
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The role of purinergic receptors in the modulation of JNK signalling endothelial and cancer cells
… as atherosclerosis.1,2 Within the MAPK family, JNK (c-Jun NH2-terminal kinase) is strongly activated by pro-inflammatory cytokines, including tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β).3,4 Thus, this project examined the potential for purinergic and cytokine receptors to …
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Investigating the role of a JNK-like MAP kinase signaling in regulating dauer developmental arrest in Caenorhabditis elegans
… of a stress-activated c-Jun Nterminal Kinase (JNK)-like mitogen activated protein kinase (MAPK), KGB-1, in dauer formation. In view of established roles of JNK MAPK in stress-activated signal transduction, the identification of the KGB-1 pathway in regulating dauer diapause is remarkable since …
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Eliminating Acute Myeloid Leukemia Stem Cells by Targeting the Niche Microenviromnent: Co-Inhibition of TNF/IL1- JNK and NF-κb
… TNF and IL1 also stimulate activation of JNK signaling which operates in parallel to NF-kB in LSCs and HSPCs. I found that JNK stimulation results in cell death in HSPCs by subsequent inactivation of pro-survival Bcl-2 family proteins by phosphorylation. However, LSCs convert JNK-mediated …
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Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia
… activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process. However, c-jun expression has not been investigated in acute myeloid leukemia (AML) cells containing the most common chromosomal translocations. t(8;21) is one of …
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The Role Of ROS-mediated ERK and JNK Activation In The Induction Of Autophagy And Apoptosis In Tumour Cells By A Novel Small Molecule Compound
… kinase (ERK) and c-Jun N-terminal kinase (JNK). Inhibition of ERK and JNK virtually completely blocked drug-induced autophagy and apoptosis. Interestingly, inhibition of JNK activity reversed C1-induced increase in Atg7 expression, indicating that JNK may regulate the autophagic pathway by …
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Elucidating binding modes of zuonin A enantiomers to JNK1 via in silico methods
Aberrant JNK signaling can result in two main forms of disease in humans: 1) neurological, coronary, hepatobiliary, and respiratory diseases and 2) autoimmune, inflammatory, and cancer conditions. Enantiomers of the lignan zuonin A, (-)-zuonin A and (+)-zuonin A, have been shown to bind to JNK …
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The scaffold protein POSH regulates T lymphocyte function
… (TCR) mediated cJUN NH2-terminal kinase (JNK) activation is required for mounting proper T cell mediated immune responses. However, little is know as to how JNK activation is coupled to the TCR. This dissertation shows that the scaffold protein Plenty of SH3s (POSH) is required for optimal …
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The role of c-Jun N-terminal kinase one and two in motoneuron maturation and maintenance
… and Wiese, 2006). The c-Jun N-terminal kinases (JNKs) are stress-activated members of the MAPK family, which may represent candidate molecules whose signaling is important in MN death, survival, differentiation, maturation, and maintenance. Classically considered a degenerative signal, JNK may be …
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Cytokine-Induced Igf-I Resistance in Progenitor Muscle Cells
… myogenin and MyoD. Furthermore we show that JNK is a key downstream intermediate by which TNFalpha and ceramide inhibit the IGF-I myogenic activity. TNFalpha, C2-ceramide and N-SMase potently induce JNK enzymatic activity. Active JNK associates with IRS-1, and this is a possible mechanism by …
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
… for the activation of c-Jun N-terminal kinases (JNK) without the involvement of its natural ligand TRAIL. In the current study, factors associated with DR5 that are involved in JNK activation are identified. Also, the involvement ofTRAF2, FADD, caspase-8, caspase-10 and RIP1 in JNK activation …
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Phagosome proteomes in activated macrophages
… suggest the specific recruitment of TAK1/MKK7/JNK signalling to the phagosomes in AAMΦ, which was confirmed by immunoblotting and fluorescence microscopy. I uncovered that K63 polyubiquitylation of phagosomal proteins is enhanced in AAMΦ, which is responsible for the translocation of TAK1 …
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Klonierung und funktionelle Analyse des Aktinreorganisators p150-Spir
Die c-Jun-N-terminale Kinase (JNK), ein Mitglied der Familie der MAP-Kinasen (Mi-togen Activated Protein Kinases), wirkt als signalübertragender Effektor, der den klei-nen GTPasen der Rho–Familie Rac und Cdc42 nachgeschaltet ist. Rho-GTPasen spielen eine Schlüsselrolle in der Regulation von …
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Mechanisms of High Glucose-induced Decrease in β-cell Function
… involve endoplasmic reticulum (ER) stress and JNK. The model of β-cell glucotoxicity was achieved by prolonged i.v. glucose infusion (to achieve hyperglycemia). In Study 1, 48h glucose infusion increased total and mitochondrial superoxide levels in islets, and impaired β-cell function in vivo …
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Wirkung der proinflammatorischen Zytokine TNFα und IL-1β auf die Aktivität und die Proteinmenge der Dual-Leucine-Zipper-Bearing Kinase in einer Betazelllinie
… Zelltodes, da sie neben der Aktivierung der JNK mit ihren proapoptotischen Einflüssen auch den Transkriptionsfaktor CREB inhibiert, wodurch dessen antiapoptotische Funktion reduziert wird. In der vorliegenden Arbeit wird der Einfluss besagter Zytokine auf die katalytische Funktion der DLK und …
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