Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"JAK3"”.
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Role of JAK3 in Myogenic Differentiation
… and differentiation; however, the role of JAK3 in myoblast differentiation remains unclear. In this study, we investigated the effect of JAK3 inhibition on myogenic differentiation in the C2C12 mouse myoblast cell line. During myogenic differentiation, treatment with the JAK3 inhibitor …
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The role of JAK1 and JAK3 in CD8<sup>+</sup> effector T cells
… the role of the tyrosine kinases JAK1 and JAK3 in cytokine signalling, focusing on interleukin-2 signalling in CD8<sup>+</sup> effector T lymphocytes. Initial experiments compared the effects of the pan JAK1/JAK3 inhibitor tofacitinib, the selective JAK1 inhibitor GSK186, and the selective …
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Protective effect of JAK3 inhibition on growth factor deprivation induced neural progenitor cell death
… understood. In the brain, a specific JAK3 inhibitor aids in the survival of a transgenic amyotrophic lateral sclerosis mouse model. We previously reported that JAK3 inhibition induced neuronal differentiation accompanied by neurite outgrowth in enriched condition of GFs such as EGF, …
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Expression und Aufreinigung von intrazellulären Anteilen des Interleukin-4-Rezeptors als GST-Fusionsproteine und Messung von Protein-Protein-Wechselwirkungen
… hingegen konnte eine Wechselwirkung mit Jak3 nicht gezeigt werden. Beide Proteine sind in der Lage, STAT5 zu präzipitieren; diese Bindung erscheint unabhängig von der IL-4 Stimulation der Zellen und läßt neue Spekulationen über den Mechanismus der Signaltransduktion durch STAT5 zu. Danach …
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QUANTITATIVE PROTEOMIC APPROACHES TO STUDY DRUG MECHANISM OF ACTION
… addition to BTK, two additional protein kinases JAK3 and BLK have been identified modified on cysteine 909 and 319, respectively. These cysteines are located in the ATP-binding site of the two kinases in a position corresponding to the cysteine 481 in BTK. Interaction with ibrutinib for JAK3 and …
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Color stability and phenolic composition from corn pericarp extracts in a beverage model and protective and anti-inflammatory potential of anthocyanin-rich plant extracts on celiac disease in vitro
… plant extracts to inhibit CTP and JAK3 has positive implication for human health; these extracts could potentially decrease the occurrence of inflammation for gluten sensitive individuals.