Global ETD Search
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Showing 1 to 4 of 4 for “"JAK2V617F"”.
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Implementation of the JAK2V617F mutation analysis in the pathway of suspected myeloproliferative neoplasms in Groote Schuur Hospital
We studied the implementation of JAK2 mutation analysis in conjunction with the World Health Organisation (WHO) guidelines in the pathway to MPN diagnosis in 279 patients presenting with one of three clinical scenarios: erythrocytosis, OR leukocytosis and/or thrombocytosis and/or splenomegaly; OR …
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Caracterização clínica e molecular de pacientes com neoplasia mieloproliferativa crônica- cromossomo Ph- negativo
A descoberta da mutação JAK2V617F foi um marco diagnóstico para pacientes com neoplasias mieloproliferativas crônicas (NMPC) – cromossomo Filadélfia (Ph) negativo. Esta mutação encontra-se, presente em quase todos os pacientes com policitemia vera (PV, 97%) e em cerca de 50% dos pacientes com …
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Exploring the role of the arginine-methylation writer-reader pair PRMT5/SND1 in JAK2-mutant myeloproliferative neoplasms
… options are limited. Discovered in 2005, the JAK2V617F mutation is the most common driver mutation in BCR-ABL negative MPNs, resulting in constitutive activation of the JAK2 protein and the JAK-STAT signaling pathway. A role for the methyltransferase activity of Protein Arginine …
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Investigating the anti-leukaemic effect of tamoxifen in the myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) commonly result from the acquisition of somatic mutations affecting the Janus kinase 2 (JAK2) (such as JAK2<sup>V617F</sup>) or the multi-functional protein CALR (such as CALR<sup>Ins5</sup> and CALR<sup>Del52</sup>), causing the constitutive activation of signal …