Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"JAK2"”.
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Role of JAK2 in the Proliferation of Activated Astrocytes
… mediators, which might be associated with JAK2/STAT pathway. Although the inhibition of JAK2 pathway might be able to mitigate the astrogliosis, it is not yet confirmed in vivo study and the role of JAK2 especially on proliferation. In the present study, systemic administration of AG490, a …
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Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
… therapeutic agents that specifically inhibit Jak2 kinase, thereby suppressing tumor cell growth. Tyrphostin AG490, the first described Jak2 inhibitor, displays poor pharmacology and requires high concentrations for anti-tumor activities. Our research group screened a small library of AG490 …
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Overcoming Resistance to CDK4/6-targeted Therapy Using JAK2/STAT3 Inhibitor in Triple-Negative Breast Cancer
… that the interleukine-6 (IL-6)/Janus kinase 2 (JAK2)/signal transducer and activation of transcription 3 (STAT3) signaling pathway is significantly correlated with CDK4/6i resistance signature in breast cancer, and its co-activation with CDK4/6 pathway is significantly enriched in TNBC patients. …
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Exploring the role of the arginine-methylation writer-reader pair PRMT5/SND1 in JAK2-mutant myeloproliferative neoplasms
… options are limited. Discovered in 2005, the JAK2V617F mutation is the most common driver mutation in BCR-ABL negative MPNs, resulting in constitutive activation of the JAK2 protein and the JAK-STAT signaling pathway. A role for the methyltransferase activity of Protein Arginine …
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Characterization of Jak, Stat, and Src Interactions In Head and Neck Squamous Cell Carcinoma
… Src inhibition, STAT5 remains inactive, but Jak2 and STAT3 are reactivated following their early inhibition. To further characterize the mechanism of this novel feedback pathway we performed several experiments to look at the interactions between Src, Jak2, STAT5 and STAT3.</p> <p>We …
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The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines ©
The receptor activator of nuclear factor-kB (RANK) and its ligand, RANKL has have been implicated as an important link between breast cancer and metastasis to bone because of their ability to activate intracellular signal cascades leading to altered cancer cell behaviour and bone breakdown. The …
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Single-cell approaches reveal functional and molecular heterogeneity in malignant haematopoietic stem cells
… in mouse haematopoietic stem cells (HSCs), using JAK2 V617F mutant myeloproliferative neoplasms (MPNs) as a model. This study utilises single-cell gene expression and functional assays to identify a subset of JAK2 V617F mutant HSCs that display defective self-renewal. This defect is rescued by …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
… (JAK/STAT) signaling, and particularly JAK2-dependent signaling, contributes to cochlear resilience during aminoglycoside ototoxic stress. To nominate candidate pathways, early gentamicin-responsive hair-cell transcriptomic data were integrated with LINCS/L1000 perturbational …
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Investigating the anti-leukaemic effect of tamoxifen in the myeloproliferative neoplasms
… somatic mutations affecting the Janus kinase 2 (JAK2) (such as JAK2<sup>V617F</sup>) or the multi-functional protein CALR (such as CALR<sup>Ins5</sup> and CALR<sup>Del52</sup>), causing the constitutive activation of signal transducer and activator of transcription (STAT) proteins. The selective …
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Implementation of the JAK2V617F mutation analysis in the pathway of suspected myeloproliferative neoplasms in Groote Schuur Hospital
We studied the implementation of JAK2 mutation analysis in conjunction with the World Health Organisation (WHO) guidelines in the pathway to MPN diagnosis in 279 patients presenting with one of three clinical scenarios: erythrocytosis, OR leukocytosis and/or thrombocytosis and/or splenomegaly; OR …
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Neuroprotection of AG490 in Oxidative Stress-induced Neuronal Death
… whether AG490, a specific Janus kinases 2 (JAK2) inhibitor had an effect on oxidative stress-induced cytotoxicity in cultured primary cortical neurons. AG490 significantly protected neuronal cell death against various oxidative stimuli, such as hydrogen peroxide (H2O2), …
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The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity
… examined genotype-phenotype associations of JAK2 and MPL mutations, the presence of clonal diversity in the MPD and the genetic events associated with progressive disease. Mutations in MPL were identified in 4% of ET and 7% of IMF but not in PV. Three different acquired MPL mutations were …
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Μοριακοί μηχανισμοί ελέγχου της μετάδοσης του σήματος της αυξητικής ορμόνης σε παιδιά με σοβαρή ανεπάρκεια στην αύξηση
… υποδοχέα GHR ή συμμετέχουν στην αποδόμηση του JAK2/GHR μέσω ουβυκουιτίνης/προτεασώματος. Η αδυναμία φωσφορυλίωσης του STAT3 και JAK2 φαινεται να προσπερνάται με χρήση εναλακτικής οδου. Με ‘διασυνομιλία’ της GH με το μονοπάτι του EGF. Συγκεκριμένα η GH φωσφωρυλιώνει το EGFR μέσω φωσφορυλίωσης …
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The molecular pathogenesis of myeloproliferative neoplasms
… are characterised by a single acquired mutation, JAK2 V617F. My study has<br/>focused on four principal areas:<br/><br/>(i) Involvement of V617F in other myeloid disorders. After developing sensitive methods to<br/>detect and quantify V617F, this mutation was identified in 17% of cases of atypical …
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Genomics, Diagnosis, Novel Targeted Therapies and Characterisation of the Drivers of Relapse in Philadelphia Chromosome-Like Acute Lymphoblastic Leukaemia
… standard responses previously published for the JAK2 inhibitor ruxolitinib, authenticating methods for determining lethal dose 50 (LD50). It was demonstrated that combination inhibitors would be more effective against JAK fusions known to confer particularly poor prognosis. In an in vitro model, …
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Inferring Clonal Dynamics in Blood using Single-Cell Measurements
… clonal disorders driven most frequently by the JAK2-V617F mutation, which arises in a single hematopoietic stem cell (HSC) and ultimately dominates the normal process of blood cell production. Although all patients carry the same driver mutation, they still branch into three distinct disease …
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The Role of Prolactin in the Cellular Response to DNA Damaging Agents
… Hsp90alpha, is a prolactin-Janus kinase-2 (Jak2)-signal transducer and activator of transcription-5 (Stat5) regulated gene in breast cancer cells. We have now observed that prolactin increased the viability of breast cancer cells to DNA damaging chemotherapeutics, and Hsp90 inhibitors, 17AAG …
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Symmetric signaling by an asymmetric 1 erythropoietin : 2 erythropoietin receptor complex
… a proliferative response and activation of the JAK2 Stat5 signaling pathway. A truncated erythropoietin receptor with only one cytosolic tyrosine (Y343), on only one receptor monomer is sufficient for signaling in response to erythropoietin, regardless of the monomer on which it is located. The …
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