Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"JAK-STAT pathway"”.
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Inactivation of the JAK-STAT Pathway
<p>Signaling pathways involving Janus kinases (JAKs) and Signal Transducers and Activators of Transcription (STATs) play an important role in cytokine-induced gene transcription. Aberrant stimulation of this pathway can lead to abnormal development and cellular transformation demonstrating the …
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Jak-stat pathway in the control of mycobacterial infections
Though mammalian JAKs and STATs have been extensively studied over the past 20 years, many aspects of their in vivo function remain unclear. In particular, their roles in control of infection with pathogens remain murky and confusing. One difficulty in understanding how these pathways regulate …
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Role of Jak/Stat pathway in the pathogenesis of breast cancer
The Jak/Stat signaling cascade mediates cell proliferation, differentiation, survival, apoptosis and immune responses. Aberrant activation of this pathway mediates neoplastic transformation and abnormal growth of many malignancies including breast cancer, the most common cancer among women, and the …
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Identification of the presence and activity of the JAK-STAT pathway in canine solid tumors
Background: The JAK-STAT pathway is a cellular signaling pathway, which acts normally in humans and animals in the control of multiple important functions. Dysregulation of this pathway has been identified in human cancers, as well as a limited number of veterinary cancers. Objectives: The aims of …
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The Role of STAT and the Jak/STAT Pathway In Mediating the Effects of Interleukin-6 on StAR Expression
… or HPA axis. This HPA axis is the major release pathway used during acute stress, during which the levels of ACTH parallel those of cortisol. However, in states of chronic stress, the level of ACTH drops dramatically, while cortisol remains high. This study focuses on the pathway of cortisol …
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The role of the systemic inflammatory response, the JAK STAT pathway and the MAPK pathway in the prognosis of resectable pancreatic cancer
Pancreatic cancer is a devastating disease with a five year survival of only 2-3%. Only 10-15% of patients have resectable disease at presentation and the only potential cure is major surgery with adjuvant chemotherapy. The outcomes of surgery are disappointing with a median survival of only15-17 …
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Role of interleukin-6 signaling via the Jak/Stat pathway in human myeloma and effects on mediators of cell survival and proliferation
… Transducer and Activator of Transcription (STAT) proteins. We report that one STAT family member Stat3, is constitutively activated in bone marrow mononuclear cells from patients with multiple myeloma and in the IL-6-dependent human myeloma cell line, U266. U266 cells are shown to …
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Effects of DFO-Induced Hypoxia on Key Signaling Mediators
… the DFO insult also displayed activation of the JAK/STAT pathway through Western blot analysis. Due to activation, the suppressors of cytokine signaling (SOCS) proteins, negative regulators of the JAK/STAT pathway, were investigated and detected via RT-PCR. These results suggest that there is an …
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Chemical Induced Hypoxia Differentially Affects Gene Expression in Human Neuronal Cells
… Western blot analysis showed the Janus kinase (JAK)/ Signal Transducers and Activators of Transcription (STAT) pathway was activated and an increase in STAT3 (P-STAT3) levels at was observed at 12 and 24 hour treatment. Heavy metal compounds such as cobalt chloride (CoCl<sub>2</sub>) can also …
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The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia
… a role on the regulation of several signaling pathway such as NF-kB, MAP kinase, JAK-STAT, and PI3 kinase. However, the roles of SHP-2 in brain microglia activation are largely unknown. Here, I determined the regulation of SHP-2 on JAK-STAT signaling pathway in brain microglia. This study …
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Improving outcomes for obese children with Acute Lymphoblastic Leukaemia (ALL): a clinical collaboration to understand the influence of obesity on treatment success.
… weight gain and MRD risk. To achieve this weight status and BMI was recorded and blood plasma was tested using human adipokine arrays at diagnosis and following induction therapy to establish if these changes correlated with weight gain or MRD risk.We have shown that MRD risk status at the end of …
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Potential oxygen-dependent regulation of PIAS3
Protein inhibitor of activated STAT3 (PIAS3), a regulator of the JAK/STAT pathway, binds to and blocks the DNA-binding activity of signal transducer and activator of transcription 3 (STAT3). PIAS3 has the potential to be hydroxylated at a specific proline residue, in an amino acid sequence known to …
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Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
… wherein AR agonists promote a more luminal state as a consequence of inhibiting oncogenic pathways. Sustained treatment of ER-positive breast cancer in vitro and in vivo with AR agonists results in rearrangement of AR, ER, and FOXA1 cistromes, transformation of tumor suppressor AR into …
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Mechanisms of microglia induced retinal degeneration
… activated by inflammatory cytokines through the JAK/STAT pathway of cytokine receptors. Suppressor of cytokine signalling 3 (SOCS3) negatively regulates the JAK/STAT pathway. In this study, a mouse strain with the deletion of two inhibitory genes (CX3CR1 and SOCS3) in myeloid cells was created …
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Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
The Jak-stat pathway is critical for cellular proliferation and is commonly found to be deregulated in many solid tumors as well as hematological malignancies. Such findings have spurred the development of novel therapeutic agents that specifically inhibit Jak2 kinase, thereby suppressing tumor …
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Prostanoid-mediated Inhibition of IL-6 Trans-Signalling in Pulmonary Arterial Hypertension: a Role for Suppressor of Cytokine Signalling 3?
… arterial hypertension (PAH) is a rare, devastating disease with no cure. Current treatment consists of a cocktail of vasodilators which relieve symptoms of PAH but do not treat the cause. Thus, there is a need for novel drugs that target the underlying pathological causes of PAH. PAH is a …
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A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
<p>The JAK-STAT pathway is a major signaling pathway involved in many biological processes including proliferation, apoptosis, and differentiation. Aberrant expression of STATs has been reported in multiple human cancers and murine mouse models of tumorigenesis. Previous studies from our lab and …
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Dissecting the impact of SMAD4 loss and KRAS mutations in pancreatic ductal adenocarcinoma
… was a marked increase in iCAFs and enhanced JAK/STAT signalling in malignant cells. Targeting of the JAK/STAT pathway by JAK inhibitors selectively reduced growth of Kras G12D Smad4-deficient PDAC compared to Smad4-proficient controls. In contrast, malignant cells with Kras G12V mutations in …
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On the role of SOCS proteins in leptin signalling
… well with the amount of body fat. As an adipostat, leptin passes the blood brain barrier to inform the hypothalamus about the status of energy reserves in the body. Appropriate responses are triggered to maintain a stable body mass. Most obese individuals have developed a state of leptin …
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