Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 97 for “"JAK-STAT"”.
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Inactivation of the JAK-STAT Pathway
<p>Signaling pathways involving Janus kinases (JAKs) and Signal Transducers and Activators of Transcription (STATs) play an important role in cytokine-induced gene transcription. Aberrant stimulation of this pathway can lead to abnormal development and cellular transformation demonstrating the …
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Jak-stat pathway in the control of mycobacterial infections
Though mammalian JAKs and STATs have been extensively studied over the past 20 years, many aspects of their in vivo function remain unclear. In particular, their roles in control of infection with pathogens remain murky and confusing. One difficulty in understanding how these pathways regulate …
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Signaltransduktion durch JAK/STAT-Moleküle bei der Polyzythämia vera
… verwendete, Signaltransduktionsfaktoren - STAT1, STAT3 und JAK2 - näher untersucht. Es zeigte sich eine konstitutive Aktivierung von STAT3 in 4 von 14 Patienten mit Polyzythämia vera.
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Role of Jak/Stat pathway in the pathogenesis of breast cancer
The Jak/Stat signaling cascade mediates cell proliferation, differentiation, survival, apoptosis and immune responses. Aberrant activation of this pathway mediates neoplastic transformation and abnormal growth of many malignancies including breast cancer, the most common cancer among women, and the …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
… transducer and activator of transcription (JAK/STAT) signaling, and particularly JAK2-dependent signaling, contributes to cochlear resilience during aminoglycoside ototoxic stress. To nominate candidate pathways, early gentamicin-responsive hair-cell transcriptomic data were integrated with …
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Το Jak stat μονοπάτι στην παθογένεση και θεραπεία της ατοπικής δερματίτιδας
… ψωρίαση, οι αναστολείς των κινασών του Ιανού (JAK αναστολείς) αποτελούν σημαντικό αντικείμενο θεραπευτικής έρευνας για την ατοπική δερματίτιδα. ΜΕΘΟΔΟΙ: Πραγματοποιήθηκε ανασκόπηση της διαθέσιμης βιβλιογραφίας, αναφορικά με την αποτελεσματικότητα και την ασφάλεια των από του στόματος και …
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Characterization of Jak, Stat, and Src Interactions In Head and Neck Squamous Cell Carcinoma
… of current treatments. Proteins in the Src/Jak/STAT pathway represent potential therapeutic targets, as this pathway is hyperactive in HNSCC and it has roles in cell migration, metastasis, proliferation, survival, and angiogenesis. During short-term Src inhibition, Janus kinase (Jak) 2, and …
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Identification of the presence and activity of the JAK-STAT pathway in canine solid tumors
Background: The JAK-STAT pathway is a cellular signaling pathway, which acts normally in humans and animals in the control of multiple important functions. Dysregulation of this pathway has been identified in human cancers, as well as a limited number of veterinary cancers. Objectives: The aims of …
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Investigating how Notch, and JAK/STAT Signaling Synergistically Regulate Intestinal Stem Cell Homeostasis Using Engineered Optogenetic Alleles
… self-renewal or differentiation. The Notch, and JAK/STAT signaling pathways are central regulators of multicellular development and are vital for tissue maintenance. The interplay between the Notch, and JAK/STAT pathways required for tissue homeostasis has not been fully elucidated, particularly …
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The Role of STAT and the Jak/STAT Pathway In Mediating the Effects of Interleukin-6 on StAR Expression
… of ACTH parallel those of cortisol. However, in states of chronic stress, the level of ACTH drops dramatically, while cortisol remains high. This study focuses on the pathway of cortisol release during these chronic stress states, specifically examining the role of IL-6 with respect to STATs and …
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The role of the systemic inflammatory response, the JAK STAT pathway and the MAPK pathway in the prognosis of resectable pancreatic cancer
Pancreatic cancer is a devastating disease with a five year survival of only 2-3%. Only 10-15% of patients have resectable disease at presentation and the only potential cure is major surgery with adjuvant chemotherapy. The outcomes of surgery are disappointing with a median survival of only15-17 …
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Role of interleukin-6 signaling via the Jak/Stat pathway in human myeloma and effects on mediators of cell survival and proliferation
… Transducer and Activator of Transcription (STAT) proteins. We report that one STAT family member Stat3, is constitutively activated in bone marrow mononuclear cells from patients with multiple myeloma and in the IL-6-dependent human myeloma cell line, U266. U266 cells are shown to …
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Funktionelle Analysen deregulierter Signalwege transformierter B-Lymphozyten - Das Epstein-Barr-Virus-Onkogen LMP1
… Zellen bei. Einer dieser Signalwege ist der Jak/STAT-Signalweg. Da dessen EBV-abhängige Aktivierung bislang nur unzureichend geklärt ist, ist es Zielsetzung dieser Arbeit, die durch das Epstein-Barr-Virus vermittelte Aktivierung des Jak/STAT-Signalweges in Burkitt-Lymphomzellen näher zu …
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The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia
… signaling pathway such as NF-kB, MAP kinase, JAK-STAT, and PI3 kinase. However, the roles of SHP-2 in brain microglia activation are largely unknown. Here, I determined the regulation of SHP-2 on JAK-STAT signaling pathway in brain microglia. This study firstly shows that curcumin has …
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The Hippo Signaling Pathway in Organ Size Control and Regeneraton
… is through modulating its phosphorylation status and subcellular localization by upstream kinase complex. I obtained both genetic and cellular evidence that 14-3-3 proteins are involved in this process. I also identified three Serine residues (S111, S168 and S250 of Yki as essential for …
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Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
… wherein AR agonists promote a more luminal state as a consequence of inhibiting oncogenic pathways. Sustained treatment of ER-positive breast cancer in vitro and in vivo with AR agonists results in rearrangement of AR, ER, and FOXA1 cistromes, transformation of tumor suppressor AR into …
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Determining the Signalling Pathways that Govern Human Naive Pluripotency
… and occupy a developmentally advanced state of pluripotency comparable to mouse EpiSCs. Recent reports demonstrate that a naïve state of human pluripotency can be consistently derived either through transient histone deacetylase inhibition mediated resetting of conventional hESCs or via …
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Effects of DFO-Induced Hypoxia on Key Signaling Mediators
… the DFO insult also displayed activation of the JAK/STAT pathway through Western blot analysis. Due to activation, the suppressors of cytokine signaling (SOCS) proteins, negative regulators of the JAK/STAT pathway, were investigated and detected via RT-PCR. These results suggest that there is an …
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Multilineäre Beteiligung der Leukämogenese in der BCR::ABL1-like Akuten Lymphoblastischen Leukämie
… werden. Analysiert wurden ABL-Klassen- und JAK-/STAT-Klassen-Proben. In keiner der 10 ABL-Klassen-Proben zeigte sich eine multilineäre Beteiligung, dagegen in 3 von 10 JAK-/STAT-Klassen-Proben. Die IGH::CRLF2-Translokation konnte exemplarisch in CD33/CD13-positiven myeloischen Kompartimenten …
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