Global ETD Search
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Showing 1 to 5 of 5 for “"JAK-2"”.
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Μορφολογική μελέτη της έκφρασης των υποδοχέων κινάσης τυροσίνης Trks (υποδοχείς νευροτροφινών) και VEGFR-3 και συσχέτισή τους με την οδό μεταγωγής σήματος EpoR/ JAK-2/ STAT-5 στους όγκους εγκεφάλου του ανθρώπου
… ανεξάρτητο της ενεργοποίησης της κινάσης JAK-2, γ) η οδός μεταγωγής σήματος JAK-2/STAT-5 ενεργοποιείται από την ερυθροποιητίνη (Epo) (μέσω δέσμευσής της με τον υποδοχέα της EpoR) η οποία πρόσφατα έχει θεωρηθεί ως παράγοντας-κλειδί της αύξησης των όγκων λόγω των αντιαποπτωτικών και …
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TIMP-1: Zelluläre Funktion und Beeinflussung der Genexpression von Matrix-Metalloproteinasen in humanen Hepatomzellen
… form (STAT 1, P-STAT 1, STAT 3, P-STAT-3, JAK 1, P-JAK 1, JAK 2, P-JAK 2, Ras GAP and JNK 1) were investigated by means of western blot analysis and western blot analysis after immunoprecipitation in wild type HepG2 cells as well as TIMP-1 overexpressing hepatoma cells. In all cases the …
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Die Rolle der Janus-Kinasen-spezifischen Insertion (JSI) in JAK2
The Janus Kinase JAK2 is activated by IL-6-type-cytokines. Furthermore it plays an important role within the signal transduction of other cytokines, as for example erythropoetin and growth factors. In the Institute for Biochemistry of the RWTH Aachen, a structured model of the Kinase domain of JAK …
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Molecular Basis of Upregulation of IL-17 in Estrogen Model of Inflammation
… of positive regulators (RORγt, RORα, NF-κB, JAK-2) and decreases the activity and/or expression of negative regulators (IRF8, ETS-1). In addition, we found that estrogen epigenetically regulates IL-17 induction by miRNAs (miR-326 and miR-223). We also found that majority of IL-17 positive …
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Characterization of Jak, Stat, and Src Interactions In Head and Neck Squamous Cell Carcinoma
… of current treatments. Proteins in the Src/Jak/STAT pathway represent potential therapeutic targets, as this pathway is hyperactive in HNSCC and it has roles in cell migration, metastasis, proliferation, survival, and angiogenesis. During short-term Src inhibition, Janus kinase (Jak) 2, and …