Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"JAK/STAT signalling"”.
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The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling
… antiproliferative effects, primarily through Jak/STAT signalling. The T-cell receptor is an antigenic receptor that recognises antigenically-derived peptides in the context of the MHC complex located on an antigen presenting cell, resulting in a cellular proliferation. Although both receptors …
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Dissecting the impact of SMAD4 loss and KRAS mutations in pancreatic ductal adenocarcinoma
… was a marked increase in iCAFs and enhanced JAK/STAT signalling in malignant cells. Targeting of the JAK/STAT pathway by JAK inhibitors selectively reduced growth of Kras G12D Smad4-deficient PDAC compared to Smad4-proficient controls. In contrast, malignant cells with Kras G12V mutations in …
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Determining the Signalling Pathways that Govern Human Naive Pluripotency
… stem cells (hESCs) rely on FGF and TGFβ signalling for self-renewal, and occupy a developmentally advanced state of pluripotency comparable to mouse EpiSCs. Recent reports demonstrate that a naïve state of human pluripotency can be consistently derived either through transient histone …
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Jak-stat pathway in the control of mycobacterial infections
Though mammalian JAKs and STATs have been extensively studied over the past 20 years, many aspects of their in vivo function remain unclear. In particular, their roles in control of infection with pathogens remain murky and confusing. One difficulty in understanding how these pathways regulate …
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Identification of the molecular pathways that mediate cytokine induced immunopathology of the gut epithelium
… repurposing screen identified the Janus kinases (JAKs) JAK1 and JAK2 as the major kinases required for IFN-γ + TNF-α dependent synergistic cell death. While TNF receptor-1 (TNFR1) was also required, there was no direct dependency of cell death on TNFR1-downstream canonical apoptotic and …
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Prostanoid-mediated Inhibition of IL-6 Trans-Signalling in Pulmonary Arterial Hypertension: a Role for Suppressor of Cytokine Signalling 3?
… arterial hypertension (PAH) is a rare, devastating disease with no cure. Current treatment consists of a cocktail of vasodilators which relieve symptoms of PAH but do not treat the cause. Thus, there is a need for novel drugs that target the underlying pathological causes of PAH. PAH is a …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues that are …
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The role of JAK1 and JAK3 in CD8<sup>+</sup> effector T cells
… was to explore the role of the tyrosine kinases JAK1 and JAK3 in cytokine signalling, focusing on interleukin-2 signalling in CD8<sup>+</sup> effector T lymphocytes. Initial experiments compared the effects of the pan JAK1/JAK3 inhibitor tofacitinib, the selective JAK1 inhibitor GSK186, and the …
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The effect of Retinol Binding Protein on the Proteome of muscle cells.
… STRA6 phosphorylation, and the activation of the JAK/STAT signalling pathway. Regardless of the mechanism, reducing circulating levels of RBP may be a novel strategy for the treatment of type II diabetes. Several small molecules have been designed to promote renal clearance of RBP, thus lowering …
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An in vitro model of human yolk sac and epiblast crosstalk
Embryogenesis entails complex signalling interactions between embryonic and extraembryonic lineages. Improved embryo culture techniques have recently allowed human embryos to be cultured in vitro past the point at which they would implant in vivo, until the internationally accepted culture limit of …
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The A2A adenosine receptor: its role in suppressing vascular inflammation and its regulation by phosphorylation
… effects of adenosine are mediated by signalling through the A2AAR and activation of the A2AAR has been shown to be protective in numerous models of inflammatory disease. Little is known about the molecular mechanisms behind these effects. However, in vitro studies using cultured …