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Showing 1 to 8 of 8 for “"JAK/STAT signaling pathway"”.

  1. Exploring the role of the arginine-methylation writer-reader pair PRMT5/SND1 in JAK2-mutant myeloproliferative neoplasms

    Rubiano, Rocio, <p>0009-0002-8656-3869</p>2025

    … options are limited. Discovered in 2005, the JAK2V617F mutation is the most common driver mutation in BCR-ABL negative MPNs, resulting in constitutive activation of the JAK2 protein and the JAK-STAT signaling pathway. A role for the methyltransferase activity of Protein Arginine …

    uthsc Repository record

  2. Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma

    Laudermilch, Chelsea LeeVirginia Tech2007

    … and associated cytokine alterations occur in gestation day (GD) 14 placenta following GD9 MNU exposure, showing that fetal-maternal communication can be hindered due to MNU. In the labyrinthine layer of the placenta, we observed multifocal fibrinous necrosis of endothelial cells due to MNU, …

    vt Repository record

  3. Dissecting the Mechanisms and the Nutritional Requirements of the Expansion of Normal and Tumorigenic Intestinal Stem Cell Lineages in Drosophila melanogaster

    Lee, Wen-Chih2014

    … cell properties is critical to maintain homeostatic balance; misregulation often leads to tumors or diseases. Recently, homeostasis of the intestinal epithelium has been shown to depend on a population of molecular defined intestinal stem cells: ISCs) in both Drosophila and mammals. However, …

    wustl Repository record

  4. Role of Stat3 In Human Nk Cell Functions

    Phatarpekar, Prasad V2016

    … which mediate their signals mainly through JAK-STAT signaling pathway. Previously, we found that K562 cells genetically modified to express membrane bound IL-21 (mbIL-21), which predominantly activates STAT3, induce robust expansion and activation of human NK cells. Further investigations …

    uthsc Repository record

  5. The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia

    김, 희영2005

    … plays a role on the regulation of several signaling pathway such as NF-kB, MAP kinase, JAK-STAT, and PI3 kinase. However, the roles of SHP-2 in brain microglia activation are largely unknown. Here, I determined the regulation of SHP-2 on JAK-STAT signaling pathway in brain microglia. This …

    ajou Repository record

  6. Cytokine resistance in melanoma

    Komyod, WarapornPublikationsserver der RWTH Aachen University2007

    … of melanoma cells. Transcription factors of the STAT family are crucial in signal transduction of cytokines. Previously, it has been reported that methylation of STAT1 on a conserved arginine residue (Arg31) is important for STAT1 function and loss of this modification was proposed to be involved …

    aachen Repository record

  7. ENGINEERING BIOPHYSICAL PROPERTIES OF HYDROGELS COUPLED WITH BIOCHEMICAL CUES FROM TME TO GENERATE DIFFERENT CAF STATES IN VITRO

    WANG YUNYUN2025

    nus

  8. STATs, SOCSs jako markery dysfunkcji allograftu nerki – analiza ekspresji genów i polimorfizmów pojedynczego nukleotydu

    Humińska - Lisowska, Kinga2018

    … zapalenia mediowanego przez cytokiny są białka STAT i SOCS- elementy szlaku sygnalizacyjnego JAK/STAT mogące uczestniczyć w procesie odrzucania allograftu. Celem pracy było zweryfikowanie, czy geny STAT, SOCS i inne geny kandydujące JAK/STAT zależne i niezależne, mogą posłużyć jako miara …

    amu-pl Repository record