Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"JAGGED1"”.
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Jagged1 regulates adult neural stem cell maintenance and multipotency through activation of Notch1
… benötigen um ein aktives Signal hervorzurufen. Jagged1 gehört der Familie Delta-Serrate-Lag2 (DSL) der Notch Liganden an und ist das einzige DSL Molekül, das in der SVZ der adulten Maus exprimiert wird. Wir stellen hiermit eine Studie vor die aufzeigt, dass adulte NSZ die aus der SVZ von …
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Sodium dichloroacetate (DCA) impairs β-secretase-mediated proteolysis of the alzheimer's disease amyloid precursor protein (APP)
… on two further ADAM substrates, E-cadherin and Jagged1 was investigated in different cell lines in order to examine the substrate and cell-type specificity of DCA. Endogenous E-cadherin expression in both SW480 colorectal cancer cells and HEK-Jagged1 (HEK cells stably overexpressing Jagged1) was …
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A Genomic Approach to Identify The Notch Pathway As A Putative Tumor Suppressor In Endometrial Cancer
… Notch signaling pathway, <em>Notch4</em> and <em>Jagged1</em>. They were also identified by qRT-PCR to be significantly down-regulated in endometrial carcinomas compared to normal endometrium. Therefore, we believe the Notch signaling pathway to act as a tumor suppressor in endometrial …
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Kinetics of notch signaling during osteoclastogenesis
… receptors and 5 membrane bound ligands including Jagged1 which is known to play a role in cell-cell communication between a variety of cell types including osteoclasts and osteoblasts. Notch signaling is activated by trans-interactions between the Notch receptor and ligand located on the surface …
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A study of Notch signalling in developmental angiogenesis
… vessel network. Induction of Notch signalling by Jagged1 peptide treatment led to a decrease in tip cell formation and a sparse vessel network. Thus, the Notch pathway negatively regulates tip cell formation to promote a non-sprouting endothelial stalk cell. The Notch-regulated ankyrin repeat …
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
… lymphatic endothelial cells (HDLECs), whereas Jagged1 (Jag1) was not. In HDLECs, Notch signaling is activated in response to Vascular Endothelial Growth Factor (VEGF) or Vascular Endothelial Growth Factor-C (VEGF-C) stimulation. In vitro assays demonstrated that Notch activation inhibits HDLEC …
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The Tumor Suppressor Notch Inhibits Head and Neck Squamous Cell Carcinoma (Hnscc) Tumor Growth and Progression By Modulating Proto-Oncogenes Axl and Ctnnal1 (Α-Catulin)
… by culturing cells on immobilized NOTCH ligand, Jagged1, coated plates. Clonogenic assays and competitive cell proliferation assays was used to evaluate cell growth and proliferation. CRISPR-Cas9 system was used to knock out NOTCH1 and/or NOTCH2 in wild-type cells. Tumor growth was evaluated …
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Autonomous and non-autonomous regulation of chromatin structure during cellular senescence
Senescent cells interact with the surrounding microenvironment achieving both pro- oncogenic and tumour-suppressive outcomes. In addition to autocrine and paracrine signalling mediated by factors of the senescence-associated secretory phenotype (SASP), we have recently identified that NOTCH1 can …