Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Itch"”.
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The Slow Healing Itch
<p>Collection of poems written 2007-2010.</p>
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Molecular Mechanisms of Itch Sensations
<p>Itch is a sensation which causes scratching response to protect skin against external harmful reagents. Acute itch arises in short time period after insect bites or allergen contact. Chronic itch happens in various skin diseases such as atopic dermatitis: AD) and psoriasis. Chronic itch usually …
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Itch occurring with chronic wounds
<p>Abstract</p>
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Roles for the E3 Ligase Itch in Immune Response Modulation
… mutant strain a has implicated the E3 ligase Itch in the spontaneous inflammation that occurs in these mice. 1 RH Anaylsis of a mice suggests that the inflammatory disease is due to a dysregulated T helper type-2 immune response. In order to verify the importance of Itch inactivation in the …
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Developing druggable in vitro models for investigating itch in atopic dermatitis
Itch (pruritus) is a unique sensation that drives a desire to scratch. It can induce severe skin damage and critically affect psychological wellbeing (e.g., sleep-deprivation, body-image insecurity). To investigate the burden of itch, a survey was conducted with ~2500 women within the general …
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Investigation into the Molecular Biology of Human Genetic Sensory Disorders of Painlessness and Itch
Pain and itch are two distinct unpleasant sensations. Despite having different characteristics, both pain and itch are often disabling, particularly when those sensations persist and result in a chronic condition. Considerable research has been focused on exploring alternative treatment for chronic …
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Quantifying Nocturnal Itch And Its Impact On Sleep Using Machine Learning And Radio Signals
Today, chronic itch affects up to 15% of the population, and is associated with over $90 Billion in annual population-expenditures in the US. Despite all the interest around this area, there’s still no solution for quantifying nocturnal scratching and its impact on patients’ sleep quality in an …
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Studies on the functions of nociceptive afferents in the skin and their microvascular interactions
… responsible for fabric-evoked discomfort, itch and prickle sensation, and skin rash are defined.
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Neurochemical characterization of the rodent primary sensory system
… the sensory system, including chronic pain and itch, can be extremely devastating and, in many cases, difficult to treat. Part of the difficulty of treating such disorders is the limited understanding that we have for the multitude of chemical players involved in the communication of sensation …
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Investigating the Transcriptional Regulation of PTF1A and the Function of PRDM13 to Specify Dorsal Spinal Interneurons
… phenotype. The increased sensitivity to itch can be attributed at least in part to loss of BHLHB5;PAX2+ inhibitory neurons, known to play a role in itch. The absence of altered sensitivities in other somatosensory modalities whose information is known to be modulated in dorsal spinal cord …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
… rosacea, cutaneous anaphylaxis, and itch in vivo. Utilizing peritoneal MCs (PMCs) that express MrgprB2, we showed that the absence of GRK2 resulted in enhanced β-hexosaminidase release in response to compound 48/80 (C48/80) but significantly reduced tryptase release in response to the …
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Exploring Pain Neurobiology: Molecular Investigation of Genetic Sensory Disorders
… range lead to facially-localised, enhanced itch in childhood (Midface Toddler Excoriation Syndrome – MiTES). Observations of the CIP- and MiTES-associated polyalanine expansion mutants in a non-neuronal cell line hint at a subtle difference in PRDM12 availability that may influence the …
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Itching and Parental guilt: Parent Responses to Children's Symptoms Following Unintentional Burn Injuries
… parents. Young children experience persistent itching and emotional distress associated with the injury. Parents assume the responsibility to manage their child’s itching since young children have limited strategies to cope with the overwhelming effects of itching. Yet very little research has …
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A study of the causes and consequences of SFTPC mistrafficking in alveolar type 2 cells using novel organoid models
… genetic screens, I identified the E3 ligase ITCH as a novel effector of SFTPC processing, and confirmed its importance in SFTPC maturation by developing a genetically manipulable alveolar organoid model in which to test the consequence of ITCH depletion. Using this novel organoid system, I …
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Beyond the Image: Marilyn Monroe, Shelley Winters, and The Method
… training, and using Monroe’s The Seven Year Itch (Wilder 1955) to Bus Stop (Logan 1956) and Winters’ A Double Life (Cukor 1947), to A Place in the Sun (Stevens 1951) as case studies, this thesis aims to establish an alternative narrational legacy for Marilyn Monroe and Shelley Winters that is …
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Slow Touch and Fast Nociception: Exploration of the Interactions Between Noxious and Innocuous Mechanical Touch Sensation
… such as pressure/vibration, temperature, itch, and pain. When considering skin mechanosensation, the canonical view is that low force innocuous mechanical stimuli are encoded by cutaneous low threshold mechanosensitive receptor (LTMR) endings, innervated by fast conducting, thickly …
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Multiplexed Mapping of the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins
… for bile acids and has been implicated in itch in cholestatic liver diseases. Using the SBA assay and a proximity ligation assay, we first showed that MRGPRX4 interacts with RAMPs. We then found that the interaction of MRGPRX4 with RAMP2 causes attenuation of both basal and …
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The Role of NDFIP1 in T Cell Tolerance
… of JunB by the Nedd4 family E3 ligase Itch. Consequently, Ndfip1 limits IL-4 expression in Th2 cells. Here we present evidence that Ndfip1 also limits IL-4 expression during the differentiation of inducible Tregs (iTregs), promoting their suppressive program. Thus, by promoting iTreg …
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Modeling host responses to tick feeding and tick-borne flavivirus evolution and dispersal
… host responses such as coagulation, complement, itch responses, and immune responses. Ticks act as vectors for an extremely broad range of human and animal pathogens. Many tick-borne pathogens are significant public health risks throughout the world. In addition, even un-infected ticks cause …
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Liquid chromatography and mass spectrometry based characterization to understand the role of neuropeptides in various physiological conditions and disease states
… of neuropeptides in chronic pain and chronic itch disorders. Findings from my works will lead to better characterization of neuropeptides and advance our knowledge and understanding about how these cell-cell signaling molecules play a decisive role on various neuropathological conditions.
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