Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"IspH"”.
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ISPH fusion proteins, ISPH inhibition, and bisphosphonate mechanism of action
In the first part of this work, IspH, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate reductase was studied. In most bacteria, apicomplexan parasites, and plants, the biosynthesis of the five carbon building blocks for terpenes is carried out by IspH. It is an essential enzyme not found in humans …
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Structure and function of the terpene biosynthesis enzyme, IspH
"The protein IspH, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate reductase, is an essential enzyme in isoprenoid biosynthesis and an important drug/herbicide target. The main research in this work investigated the structures and functions of IspHs from various organisms. Using a sequence …
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ISPH Modelling of Solitary Wave Interaction with Permeable Beaches
… This thesis presents an incompressible SPH (ISPH) model that can simulate violent porous flows. In the present ISPH model, dummy particles were used to implement porous structures. These dummy particles have information on porosity, mass and density. A new water-porous interface was proposed …
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Mechanisms of action and inhibition of [4Fe-4S] proteins IspG and IspH in isoprenoid biosynthesis
… in this pathway, IspG (also known as GcpE) and IspH (also known as LytB) were largely unknown, and there were no inhibitors targeting these two enzymes. These two enzymes both are [4Fe-4S] proteins with one unique iron not bonded to any cysteine residue, and catalyze 2e-/2H+ reductions. In this …
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Mechanism, inhibition and spectroscopy of isoprenoid biosynthesis enzymes
… The first pair of enzyme are IspG and IspH, which constitute the last two steps in the MEP/DOXP (or non-mevalonate) pathway, which some bacteria, protozoa and plants rely on to produce the basic building blocks of isoprenoids, isopentenyl pyrophosphate (IPP) and dimethylallyl …
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Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors
… pyrophosphate synthase) and IspH (also know as LytB and E-4-hydroxy-2-C-methyl-erythritol pyrophosphate reductase), respectively. Investigation of novel cancer drugs focuses on mono- and combination therapies targeting the farnesyl pyrophosphate synthase (FPPS) and GGPPS …
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Drug discovery against malaria parasite: drug repositioning strategy
… work, I used drug-repositioning strategy with bisphosphonates to discover a lead that is active against malaria in vivo. The developmental procedures include, in vitro high throughput screening, x-ray crystallography and other biophysical techniques. First, a computational method was developed …