Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"IspG"”.
-
Mechanisms of action and inhibition of [4Fe-4S] proteins IspG and IspH in isoprenoid biosynthesis
… of the last two enzymes in this pathway, IspG (also known as GcpE) and IspH (also known as LytB) were largely unknown, and there were no inhibitors targeting these two enzymes. These two enzymes both are [4Fe-4S] proteins with one unique iron not bonded to any cysteine residue, and …
-
Mechanism, inhibition and spectroscopy of isoprenoid biosynthesis enzymes
… biosynthesis. The first pair of enzyme are IspG and IspH, which constitute the last two steps in the MEP/DOXP (or non-mevalonate) pathway, which some bacteria, protozoa and plants rely on to produce the basic building blocks of isoprenoids, isopentenyl pyrophosphate (IPP) and dimethylallyl …
-
Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors
… and ultimate enzymes of the MEP pathway, IspG (iron sulfur protein G; also known as GcpE and E-4-hydroxy-2-C-methyl-erythritol pyrophosphate synthase) and IspH (also know as LytB and E-4-hydroxy-2-C-methyl-erythritol pyrophosphate reductase), respectively. Investigation of novel cancer …
-
Chemical Modification of Iron-Sulfur Cofactors
… 4, we apply a similar Fe exchange method to IspG, an [Fe₄S₄] enzyme involved in bacterial isoprenoid biosynthesis, to show that the Fe sites within the [Fe₄S₄] cluster can be further differentiated in the Fe exchange kinetics and consequently that site-selective ⁵⁷Fe labeling can be achieved. …
-
Structure, function and inhibition of GcpE, FPPS and GGPPS: targeting isoprenoid biosynthesis for drug discovery
IspG, farnesyl diphosphate synthase (FPPS) and geranylgeranyl diphosphate synthase (GGPPS) are enzymes involved in isoprenoid biosynthesis. Most bacterial IspGs contain two domains: a TIM barrel (A) and a 4Fe4S domain (B), but in plants and malaria parasites there is a large insert domain (A*) …
-
ISPH fusion proteins, ISPH inhibition, and bisphosphonate mechanism of action
… along with the examination of numerous IspH and IspG structures revealed the importance of η1 σ-bonding of ligands to the fourth Fe in the 4Fe-4S cluster. Additionally, a virtual screening campaign was carried out by collaborators at the University of California – San Diego, and enzymatic testing …