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Showing 1 to 15 of 15 for “"Isoxazoles"”.
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IMPROVED SYNTHESIS OF 3-ARYL-ISOXAZOLES AS INTERMEDIATES FOR NOVEL G-QUADRUPLEX BINDING ANTI-TUMOR AGENTS
… system, methods traditionally used to synthesize isoxazoles were inefficient and gave poor yields. A critical comparison of methods to prepare sterically hindered 3-aryl isoxazoles containing fused aromatic rings using the nitrile oxide cycloaddition (NOC) revealed that modification of the method …
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IMPROVED SYNTHESIS OF 3-ARYL-ISOXAZOLES AS INTERMEDIATES FOR NOVEL G-QUADRUPLEX BINDING ANTI-TUMOR AGENTS
… system, methods traditionally used to synthesize isoxazoles were inefficient and gave poor yields. A critical comparison of methods to prepare sterically hindered 3-aryl isoxazoles containing fused aromatic rings using the nitrile oxide cycloaddition (NOC) revealed that modification of the method …
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Novel addition reactions of some benzopyrans
… with hydroxylamine to give benzopyrano[3,4-d]isoxazoles and base catalysed ring opening of the isoxazoles. The reaction of 2-isopropylchroman-4-one with ethyl formate yielded a rearrangement product, 3-(2-methylprop-l-enyl)chromone. The reaction of 2-cyclopropyl-2-methyl-3- …
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Preparation and Cycloaddition Reactions of Oxazoline Nitrogen Oxides
… however, led to the formation of isoxazoles. Competitive experiments demonstrated that 2,4,4-trimethyloxazoline N-oxide is at least 6,800 times more reactive toward phenyl isocyanate than the analogous 2,5,5-trimethylpyrroline N-oxide, and is 160 times more reactive toward dimethyl …
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Synthesis of functionalised sulfonamides
… chemistry were carried out. The synthesis of isoxazoles from isoxazolidines was explored, and in the process a novel tertiary amine catalysed 'cycloaddition' has been discovered. The resulting isoxazolidine products were assessed as potential biological probes against various enzymes/diseases, …
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Site-Specific Labelling of Nucleic Acids by Catalyst-Free 1,3-Dipolar Cycloadditions
… cycloadditions to a simple alkyne, the isomeric isoxazoles were obtained in excellent yields. Functional group interchange of the pendant hydroxy group to a phosphoramidite functionality facilitated coupling to DNA both by manual and instrument controlled solid phase DNA synthesis. …
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Reactions and rearrangements of chroman-4-ones and related compounds
… have been used to prepare a range of benzopyrano isoxazoles, pyrazoles. pyrroles and pyrimidines. 3-Hydroxymethylenespiro[chroman-2. 1 '-cyclopentan]-4-one is particularly unstable to acid-base conditions. Attempts to prepare this compound resulted only in the formation of 3-(1 …
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Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter
… targets. MARS proved to produce isoxazoles with the open hydrazone form predominating, constituting a complete SAR series, and exhibited robust activity in biological assays.
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Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter
… targets. MARS proved to produce isoxazoles with the open hydrazone form predominating, constituting a complete SAR series, and exhibited robust activity in biological assays.
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BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Concentrations of L-glutamate in the CNS are regulated by a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby …
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BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Concentrations of L-glutamate in the CNS are regulated by a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby …
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Development of site-specific RNA labeling strategies to probe alternative RNA splicing
… in three or six steps,including triazoles, isoxazoles, thiophenes and pyrazoles. Attempts to install an azide moiety to the guanosine were partly successful, but the strategy was abanonded due to reaction reproducibility issues. In addition, a C-H activation strategy was not successful on …
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DESIGN, SYNTHESIS AND CHARACTERIZATION OF ISOXAZOLE CONTAINING GLUTAMATE ANALOGS
Ligands targeting the glutamate binding proteins, both the glutamate receptors and transporters hold a great potential as medicinal agents for a wide variety of neurological disorders. In an attempt to synthesize these ligands, a number of synthetic routes have been explored. Many important …
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DESIGN, SYNTHESIS AND CHARACTERIZATION OF ISOXAZOLE CONTAINING GLUTAMATE ANALOGS
Ligands targeting the glutamate binding proteins, both the glutamate receptors and transporters hold a great potential as medicinal agents for a wide variety of neurological disorders. In an attempt to synthesize these ligands, a number of synthetic routes have been explored. Many important …
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Síntesis de compuestos organoselénicos derivados del hidroxitirosol. Determinación de su actividad como antioxidantes
… un solo paso y en ausencia de disolvente a los isoxazoles 74 y 75. (Esquema 14) Esquema 14 2.5. Ensayos de capacidad antioxidante El objetivo principal de los ensayos de antioxidación es estudiar la actividad antioxidante de las estructuras derivadas del hidroxitirosol anteriormente descritas, …