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Showing 1 to 20 of 39 for “"Isoxazole"”.

  1. DESIGN, SYNTHESIS AND CHARACTERIZATION OF ISOXAZOLE CONTAINING GLUTAMATE ANALOGS

    SHARMA, SHIKHA

    … synthesized and reaction conditions optimized. Isoxazole containing glutamate analogs have played a very important role in delineating the selectivity among glutamate binding proteins in the central nervous system (CNS). The binding studies on some of the previously synthesized isoxazole analogs …

    montana-tech Repository record

  2. DESIGN, SYNTHESIS AND CHARACTERIZATION OF ISOXAZOLE CONTAINING GLUTAMATE ANALOGS

    SHARMA, SHIKHA

    … synthesized and reaction conditions optimized. Isoxazole containing glutamate analogs have played a very important role in delineating the selectivity among glutamate binding proteins in the central nervous system (CNS). The binding studies on some of the previously synthesized isoxazole analogs …

    montana Repository record

  3. Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter

    Matti, Afnan Lilly

    … acid (NMDA). (RS)-2-amino-3-(3-hydroxy-5-methylisoxazole-4-yl) propionic acid (AMPA), and kainic acid (KA) receptors, and the fourth heterogeneous class is the metabotropic EAA receptor (mGluRs). It is now generally agreed that iGluRs as well as subtypes of these receptors are potential targets …

    montana-tech Repository record

  4. Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter

    Matti, Afnan Lilly

    … acid (NMDA). (RS)-2-amino-3-(3-hydroxy-5-methylisoxazole-4-yl) propionic acid (AMPA), and kainic acid (KA) receptors, and the fourth heterogeneous class is the metabotropic EAA receptor (mGluRs). It is now generally agreed that iGluRs as well as subtypes of these receptors are potential targets …

    montana Repository record

  5. Synthesis and chemosensing ability of novel pyrene-isoxazole-calix[4]arene constructs

    Diao, HaowenNational University of Ireland Maynooth2012

    … following elements: a pyrene reporter unit, an isoxazole unit functioning as linker and ion-binding moiety and calixarene scaffold as ion-binding moiety - PIC.

    maynooth Repository record

  6. Isoxazole Linked siRNA Cholesterol Conjugates by Catalyst Free Nitrile Oxide/Alkyne Cycloadditions

    Algay, VirginieNational University of Ireland Maynooth2012

    … and nitrile oxides. Unfortunately the pyrrolo-isoxazole skeleton resulting from cycloaddition to the maleimides was unstable to the standard conditions of oligonucleotide cleavage and thus Chapter 2 concludes that the plan to prepare chemically modified oligonucleotides by cycloaddition to …

    maynooth Repository record

  7. Structure Activity Study of a Family of Functional Pyrene-Isoxazole-Calix[4]arene Fluorescent Chemosensors for Metal Ion Detection

    O'Sullivan, JustineNational University of Ireland Maynooth2016

    … characterisationof a novel family of pyrene-isoxazole-calix[4]arenes. Aninvestigation of their metal cation sensing abilitiesusing techniques including absorbance, fluorescence and 1H NMR spectroscopiesfollows.The novel work begins by developing apyrene-isoxazole appended calix[4]arene,PIC …

    maynooth Repository record

  8. The effect of propofol on α‐amino‐5‐methyl‐4‐isoxazole propionate(AMPA) induced neurotoxicity in rat mixed cortical cultures

    서, 명신2011

    … D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainite. The pattern of AMPA mediated neurotoxicity (necrosis vs apoptosis) and the neuroprotective effect of propofol to AMPA mediated neurotoxicity still remain unclear. We applied 72 hr, 50 μM AMPA stimulation …

    ajou Repository record

  9. PART I: THE TOTAL SYNTHESIS OF DL-ELWESINE. PART II: THE APPLICATION OF THE ISOXAZOLE NUCLEUS TO THE SYNTHESIS OF SEMICORRINS

    DUPREE, LOUIS EDWARD, JR.Rice University1971

    rice Repository record

  10. Cell-Free Formation of RNA Granules

    Han, Tina Wei2012

    … precipitation activity of a 3,5-disubstituted isoxazole compound that can be used as a quick and efficient pharmacological tool to probe the function and regulation of RNA granules. The second method utilizes a three-dimensional protein-retaining hydrogel formed from a recombinant protein. …

    utswmed Repository record

  11. Heterocycles in peptide chemistry

    Hollis, Stephen JamesThe Open University2000

    … en amine led to a Boc-protected 3-aminoalkylisoxazole amino acid ester. The nitrogen and carbon termini of this isoxazole were coupled to other a-amino acids. Analysis of the dipeptide from coupling to (S)-alanine indicated that the integrity of the chiral centre of the isoxazole had been …

    the-open-u Repository record

  12. BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP

    RAJALE, TRIDEEP

    … bioisosteres of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), including lipophilic analogs using lateral metalation and electrophilic quenching and their evaluations at the system xc- transporter. Bioisosteres which are not limited to amino acids were synthesized from a common …

    montana-tech Repository record

  13. BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP

    RAJALE, TRIDEEP

    … bioisosteres of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), including lipophilic analogs using lateral metalation and electrophilic quenching and their evaluations at the system xc- transporter. Bioisosteres which are not limited to amino acids were synthesized from a common …

    montana Repository record

  14. Site-Specific Labelling of Nucleic Acids by Catalyst-Free 1,3-Dipolar Cycloadditions

    Freeman, ColinNational University of Ireland Maynooth2012

    … building blocks generated by NOAC. Three isoxazole phosphoramidites were prepared. Following in situ generation of the nitrile oxides from 1,2-, 1,3- or 1,4-disubstituted hydroxyethoxybenzaldehyde oximes and highly regioselective cycloadditions to a simple alkyne, the isomeric isoxazoles …

    maynooth Repository record

  15. Development of site-specific RNA labeling strategies to probe alternative RNA splicing

    Kosmidis, Tilemachos D.University of Strathclyde2016

    … in three or six steps,including triazoles, isoxazoles, thiophenes and pyrazoles. Attempts to install an azide moiety to the guanosine were partly successful, but the strategy was abanonded due to reaction reproducibility issues. In addition, a C-H activation strategy was not successful on …

    strathclyde Repository record

  16. Explore the Formation of Triplet Nitrene - A Potential Intermediate for Building Organic Magnets

    Zhang, XiaomingUniversity of Cincinnati2012

    … and 5-(4-chlorophenyl)isoxazole as the photoproducts. Upon further photolysis, the proton NMR shows decompositions of (2H-azirin-2-yl)(4-chlorophenyl)methanone and 5-(4-chlorophenyl)isoxazole to form 3-(4-chlorophenyl)-3-oxopropanenitrile. Laser flash photolysis of …

    ohiolink Repository record

  17. The Extracellular Domains of the AMPA, Kainate, and Orphan Delta Receptor Regulate Channel Gating in Distinct Ways

    Gonzalez, Cuauhtemoc Ulises, <p>https://orcid.org/0000-0002-5861-7180</p>2025

    … this family, the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate receptor mediate their function through fast glutamate-gated ionotropic activity, which needs precise structural changes to perform properly. While Cryo-EM structures have provided snap shots of these …

    uthsc Repository record

  18. NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION

    Duncan, Nathan S

    … 10-oxoanthracene and substituted anthracenyl isoxazole esters (AIEs) were synthesized and characterized based on NMR studies. To date, quarfloxin is the only G-quadruplex ligand from the large number developed to progress to clinical evaluation. The synthesis, structural characterization, and …

    montana-tech Repository record

  19. NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION

    Duncan, Nathan S

    … 10-oxoanthracene and substituted anthracenyl isoxazole esters (AIEs) were synthesized and characterized based on NMR studies. To date, quarfloxin is the only G-quadruplex ligand from the large number developed to progress to clinical evaluation. The synthesis, structural characterization, and …

    montana Repository record

  20. Synthesis and Characterisation of Photoresponsive Azobenzene-Biomolecule Conjugates

    Hayden, JackNational University of Ireland Maynooth2017

    … functionality are reported. The formation of isoxazole, triazole and ether linked biomolecule conjugates is demonstrated. Peptide conjugates have been prepared by cycloaddition in solution and on the solid phase. Formation of both mono- and divalent conjugates is demonstrated and a range of …

    maynooth Repository record

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