Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Isotype class switch"”.
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Hapten Binding by Lymphocyte Surface Immunoglobulin and the Subsequent Implications for Affinity Maturation
… plasmacytoma (MOPC-315) which had experienced isotype class switch to an (alpha) heavy chain, the immunoglobulin active site was identical between the cell's smIg and secreted immunoglobulin. Protein specificity and affinity for nitrophenyl compounds were determined by quantitative affinity …
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
… both IFN-I and IFN-II were required for isotype-class switch of autoantibodies thereby the generation of pathogenic subtypes. We further determined that IFN-II was produced by natural killer (NK) cells, which contributed to the development of humoral autoimmunity. In contrast, NKT cells …
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The Effect of Activation Induced Cytidine Deaminase Phosphorylation and Herpes Virus Uracil Dna Glycosylase On Antibody Diversification
… processes of somatic hypermuntation (SHM) and isotype class switch recombination (CSR). AID is targeted to the immunoglobulin gene locus where it deaminates cytosines to generate uracil residues in DNA. This generates guanine-uracil (U:G) mismatch lesion which are recognized by uracil DNA …
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Immunoregulatory differences between adult onset type 1 diabetes and latent autoimmune diabetes in adults (LADA)
… 65 (GADA) were predominantly of the IgGl subclass in both adult onset type 1 diabetes and LADA. Moreover, the IgG4 subclass was the second most common subclass in LADA but below detection limit in type 1 diabetes at clinical onset. This suggests a larger involvement of Th2 cells in LADA …