Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Isothiocyanates"”.
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Inhibitory Effects of Isothiocyanates on the Mutagenicity and Metabolism of Environmental Carcinogens
… inhibitory effects of the two naturally occuning isothiocyanates, benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC) on the metabolism and mutagenicity of 4-(methylnitrosamino)-l-(3-pyridyl)-lbutanone (NNK) and benzo[a]pyrene (BaP) by F344 rat and male Syrian golden hamster liver …
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Broccoli Components as Antioxidants: The Role of Isothiocyanates as Redox Modifiers via Glutathiolation
… another group of dietary bioactive compounds, isothiocyanates, which do not have free radical scavenging capabilities but rather increase cellular antioxidant protection via indirect antioxidant mechanisms. Surprisingly, studies have shown that acutely, rather than acting as antioxidants, …
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Digestive metabolism of glucosinolates: a novel approach using urinary markers for estimating the release of glucosinolate breakdown products in the gastro-intestinal tract of mammals.
… a range of metabolites including beneficial isothiocyanates. Little is known about the fate of glucosinolates after their ingestion. Using urinary end-products of metabolism as markers, measurement of the production of isothiocyanates in the digestive tract of monogastric animals has been …
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Synthesis of sulfonylthioureas as anti-diabetic drugs
… of benzamido-benzenesulfonamide with four isothiocyanates. Three novel pyrrolidino benzenesulfonylthiourea 33a, 33b and 33c were obtained from the reactions of pyrrolidino benzenesulfonamide with three isothiocyanates. Five acetamido-benzenesulfonylthioureas 26a-26k were obtained from …
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Effect of benzylglucosinolate on signaling pathways associated with type 2 diabetes prevention
… nitrogen sulfur compounds (glucosinolates and isothiocyanates) and polyphenols largely associated with the prevention of cancer. Isothiocyanates (ITCs) display their anti-carcinogenic potential by inducing detoxicating phase II enzymes and increasing glutathione (GSH) levels in tissues. In T2D …
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Nematicidal, antimicrobial and acaricidal activity of plant secondary metabolites
… as α, β- and α, β, γ, δ- unsaturated aldehydes, isothiocyanates and polyphenols as potential nematicidal against the root knot nematode Meloidogyne spp. We deal also about the possible mode of action of aromatic aldehydes by the inhibition of V-ATPase of the nematode. Second, we demostrate the …
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Inflammation enhanced colon cancer & natural anti-cancer plant compounds
… through mechanisms that are not well understood. Isothiocyanates, which are the bioactive components in broccoli and other cruciferous vegetables, have been shown to suppress COX-2 and IL-6 production from inflammation. The polyacetylene gymnasterkoreayne B (GKB) was previously shown to increase …
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DERIVATIVES OF 2-BENZYLIDENECYCLOHEXANONE AS POTENTIAL ANTINEOPLASTIC AGENTS
… prepare some substituted 2-benzylidenecyclohexyl isothiocyanates, which would be screened against L-1210 lymphoid leukemia and the KB tumor. The first step in the synthesis involved the preparation of substituted (E)-2- benzylidenecyclohexanones, which are α,ß-unsaturated ketones, a class of …
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Isotopic labelling applied to the infrared spectra of metal complexes
… complexes of first transition metal(II) isothiocyanates is reported.
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Microbial glucosinolate metabolism: Characterization of Enterococcus faecalis XL1 and functional analysis of a GH4 enzyme
… in cruciferous vegetables, are hydrolyzed to isothiocyanates (ITCs) – bioactive compounds with antimicrobial, anticancer, and anti-inflammatory properties. When plant myrosinases are inactivated by cooking, gut microbes become the primary contributors to ITC formation. However, the microbial …
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Synthesis, Characterisation and Biological Activity of Silicon Nanoparticles Functionalised by Anticancer Compounds
… receptor-mediated targeting in cancer cells. Isothiocyanates (ITCs) can prevent the onset of carcinogenesis and act as chemopreventive compounds. ITC-functionalised SiNPs were synthesised using two different methods, initiated from two different types of SiNPs. The surface chemistry of these …
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Effects of Brassica on the human gut microbiota
… biologically active breakdown products, such as isothiocyanates. The effects of consuming Brassica on the composition of the gut microbiota, and the bacterial mechanisms employed for glucosinolate metabolism, are unclear, and forms the basis of the research presented in this thesis. Culturing …
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Neuroprotective Effects of Sulforaphane and the Involvement of Autophagy
… vegetables such as cauliflower or cabbage. Isothiocyanates have been researched for over 20 years in the field of cancer. They show many different bioactivities, of which the majority are positively associated with cell health and are possibly collectively responsible for protective effects …
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The Metabolic Fate of Glucoraphanin in F344 Rats
… studies show low bioavailability of dietary isothiocyanates, suggesting that there may be ways to improve bioavailability for better utilization of cruciferous vegetables in improving the public health.
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Development of a New General Click Chemistry and Applications in Bioconjugation: Part I: Rewiring Bacteria Cell Surfaces with Bio-Orthogonal Chemistry Part II: A Novel General Dialdehyde Click Chemistry for Primary Amine Conjugation
… include the use of activated carboxylic acids, isothiocyanates, Michael addition type systems and reaction with ketones or aldehydes followed by in situ reductive amination. In the second part, we introduce a new traceless, high yield, fast; click chemistry method based on the rapid and …
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The effect of a dietary phase 2 protein inducer on inflammatory parameters in blood and liver of spontaneously hypertensive stroke prone rats
… a rich source of phase 2 enzyme inducers such as isothiocyanates, can be incorporated into the diet to increase phase 2 enzymes. The hypothesis of this study is that, the dietary intake of dried broccoli sprouts, by inducing liver phase 2 enzymes, will decrease oxidative stress and the acute phase …
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Leishmanicidal, anti-inflammatory and anti-obesity properties of natural products from common medicinal and edible plants.
… (Moringaceae), which contains four bioactive isothiocyanates (MICs). Fresh leaves of M. oleifera were extracted with water to obtain a moringa concentrate (MC) containing 1.66% of total MICs. Also, MIC-1 and 4 were isolated from leaves. MC, MIC-1, and MIC-4 significantly decreased gene …
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Reaction of CS2 and CO2 with Amidines and Guanidines
… state which cleaves to form two molecules: isothiocyanates (RNCS) and thioacetamide or tetramethylthiourea (TMTU) in the case of the guanidine. Such rotation cannot happen in cyclic amidines due to their rigidity. Alkylation reactions performed on the products of the reaction of …
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The bioavailability of sulforaphane from broccoli products in men and its epigenetic activity
… of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol Biomarkers Prev. 1998 Dec;7(12):1091-100. 2. Lai RH, Miller MJ, Jeffery EH. Glucoraphanin hydrolysis by microbiota in the rat cecum results in sulforaphane absorption. Food Funct. …
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