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Showing 1 to 12 of 12 for “"Isonicotinamide"”.
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Co-crystallisation of α,ω-dicarboxylic acids with nicotinamide and isonicotinamide
… nicotinamide for n = 0, 1, 2, 4, 5, 6, 7 and isonicotinamide for n = 5, 6, 7 yielding 12 new solid materials. The melting point of the starting materials and new products are determined and analysed, and the new crystalline materials characterised using NMR, FTIR, powder X-ray diffraction data …
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Investigating co-crystallisation of primary amides and carboxylic acids. Comparative analysis of Benzamide, Isonicotinamide and Nicotinamide co-crystal growth with carboxylic acid.
… and solvent drop grinding. The comparison of Isonicotinamide and Benzamide as a co-crystal component has been presented. This study was motivated by the observation that the CSD contains 24 Isonicotinamide and 1 Benzamide co-crystal. The interaction with carboxylic acids is the focus of the …
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Impact of mixed solvent on co-crystal solubility, ternary diagrams and crystallisation scale-up. Crystallisations of Isonicotinamide ¿Benzoic Acid Co-crystals from Ethanol ¿Water Co-solvent System.
… its complementary carboxylic group, in this work isonicotinamide and benzoic acid were chosen to design co-crystal and much literature exist that introduce the determination of co-crystal growth from these two compounds. The growth of co-crystals was carried out in water, ethanol and ethanol / …
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Impact of mixed solvent on co-crystal solubility, ternary diagrams and crystallisation scale-up. Crystallisations of Isonicotinamide ¿Benzoic Acid Co-crystals from Ethanol ¿Water Co-solvent System.
… its complementary carboxylic group, in this work isonicotinamide and benzoic acid were chosen to design co-crystal and much literature exist that introduce the determination of co-crystal growth from these two compounds. The growth of co-crystals was carried out in water, ethanol and ethanol / …
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Beneficiation of selected pesticides and an antihyperlipidemic agent via cyclodextrin complexation and co-crystallization
… 4-aminobenzamide, 4-aminopyridine, benzamide, isonicotinamide, tranexamic acid and urea. NMR spectroscopy revealed 1:1 stoichiometries for all products. Their designation as salts or co-crystals was based on unequivocal evidence gleaned from single crystal X-ray structural studies, these …
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Werner clathrates: structure and selectivity
… of Ni(NCS)₂(nicotinamide)₄, H5, Ni(NCS)₂(isonicotinamide)₄, H6, and Ni(NCS)₂(nicotinamide)₂(isonicotinamide)₂, H7, whose functional groups form amide synthons, generated specific packing patterns which were examined in this thesis. Guests such as amides, alcohols and ketones were located …
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The preparation and characterization of multi-component systems in drug pre-formulation
… a new polymorph of one of the co-formers, namely isonicotinamide, was discovered serendipitously and thoroughly characterized using thermal analysis and single crystal X-ray diffraction. Phase solubility studies with a variety of CDs showed that the poor aqueous solubility of allopurinol and …
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Structural investigations with high pressure techniques and multicomponent systems
… two stoichiometric ratios of benzoic acid and isonicotinamide (2:1 & 1:1) were investigated. The rate of compression in these systems are almost identical despite the different molecular packing in each of the stoichiometric ratios. Through the investigation of materials in these initial …
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Synthesis and characterisation of new multi-component compounds containing the non-steroidal anti-inflammatory drugs fenbufen and S(+)-ibuprofen
… an ionic co-crystal consisting of fenbufen and isonicotinamide (FEN-ISN) with 2:3 stoichiometry. Salts of S-(+)-ibuprofen with the antifibrinolytic agents 6-aminocaproic acid [(S-IBU)- (ACA)+ ] and tranexamic acid [(S-IBU)- (TXA)+ ] were successfully synthesised and comprehensively …
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Hydrogen transfer in hydrogen bonded solid state materials
… for the proton. The molecular complexes of isonicotinamide with oxalic acid crystallise in two hydrogenous polymorphs and, upon substituting the acidic hydrogen for deuterium, in two deuterated polymorphs, neither being isostructural to the hydrogenous forms. This phenomenon is known as …
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Study of the highly oxidizing centers in the metmyoglobin-H2O2 reaction
… (a 4 LRu; a = NH 3 ; L = NH 3 , pyridine, isonicotinamide). The reduction potentials (Ru III/II ) of the Mb-bound complexes were determined to be 77, 330, and 400 mV for the a 5 Ru, a 4 PyrRu, and a 4 IsnRu derivatives, respectively. The kinetics of Fe IV = O heme reduction in Mb by a 4 LRu …
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The supramolecular modification of trans-resveratrol and related antioxidant molecules
… and the GRAS compounds nicotinamide (NIC) and isonicotinamide (ISO) by coprecipitation, and were fully characterised. Single crystal X-ray diffraction confirmed the formation of cocrystals rather than salts. Analysis using ¹H NMR spectroscopy for quantitation revealed that the aqueous …