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Showing 1 to 12 of 12 for “"Isomerases"”.
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Identification of Peptidyl-prolyl cis/trans isomerases affecting Drosophila circadian rhythms
ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF FIGURES ⅴ LIST OF TABLES ⅵ Ⅰ. INTRODUCTION 1 Ⅱ. MATERIALS AND METHODS 5 A. PPIase genes in Drosophila melanogaster 5 B. Knockdown fly strains 7 C. Fly behavioral assays 7 D. Plasmids and methods for S2 cell-based assays 8 E. Immunoblotting 8 F. …
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The chemistry and evolution of enzyme function: isomerases as a case study
… structural rearrangements between isomers, the isomerases (EC 5). A comprehensive analysis of the overall chemistry of isomerase reactions based on bond changes, reaction centres and substrates and products revealed that isomerase reactions are chemically diverse and difficult to classify using …
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Analysis, fractionation and exploratory recombinant expression of novel eukaryotic l/D peptide isomerases and free D-amino acid racemases
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Defining the human endothelial transcriptome
… acid binding proteins, cytoskeletal proteins and isomerases as well as certain known markers of endothelium, and the complete list of genes can be found at ... We have also studied the effect of a 4-hour exposure of HUVEC to 10 U/mL of IL-1, and detected 491 upregulated and 259 downregulated …
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ELUCIDATING THE MOLECULAR DETERMINANTS OF P53-MEDIATED PLEIOTROPIC EFFECTS IN SMALL CELL LUNG CANCER
… cyclophilin family of peptidyl prolyl cis-trans isomerases as critical determinants of a p53-induced transcriptional program that is specific to SCLC tumors and cell lines that are poised to undergo p53-mediated necrosis. Importantly, inhibition of cyclophilin isomerase activity, or genetic …
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Disulfide Bond Formation: Identifying Roles of PDI Family Thiol Oxidoreductases and ER Oxidant Pathways
Protein disulfide isomerases (PDIs) catalyze the oxidation and isomerization of disulfide bonds in proteins passing through the endoplasmic reticulum (ER). Although as many as 20 enzymes are classified as PDI family members, their relative contributions to protein folding have remained an open …
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Design, Synthesis, & Biological Evaluation of Novel Het-Aromatic/Aromatic Analogs for the Treatment of HIV, Cancer, & Cognitive Dysfunctions
<p>Cyclophilin A are a class of peptidyl-prolyl isomerases that catalyzes isomerization of the proline residue within a protein. Cyclophilin A plays an instrumental role in the pathogenesis of HIV and HCV virus. Using structure-based drug we designed and synthesized small molecule inhibitors of …
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Biochemical and structural studies of histone and associated proteins from chick and human nuclei
… cePNE1 is rich in HMG proteins, peptidyl-prolyl isomerases (FKBP3) and heatshock protein 70 which were fractionated by cation-exchange chromatography and anion-exchange chromatography (Chapter 3). Valuable (in terms of function) high-molecular-weight proteins were enriched, and another group of …
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PURIFICATION AND INTERACTION STUDIES OF HISTONE, HMGB, AND PPI PROTEINS, FACILITATED BY THE DIPOLAR NATURE OF HMGBS
… was developed for isolating the peptidyl-prolyl isomerases FKBP3 and Cyp B.
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REGULATION OF EUKARYOTIC TRANSCRIPTIONAL ELONGATION AND ASSOCIATED DNA REPAIR
… at RNAPII-CTD undergo isomerization by proline isomerases, which also regulate transcription. One of the proline isomerases, Rrd1p, has been previously implicated in transcription in response to rapamycin treatment. Based on this fact and Rrd1p’s known interaction with RNAPII-CTD, we predicted …
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Characterisation of quiescin-sulfhydryl oxidase and nematode astacin mutants using functional studies in caenorhabditis elegans.
… cuticle formation, namely the protein disulphide isomerases. There are three distinct QSOX family members found within the C. elegans genome, which have been shown to temporally coincide with lethargus (cuticle synthesis) and have been proven to spatially localise to the C. elegans hypodermis, the …
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Purification and Properties of Triosephosphate Isomerase from Selected Chlorophyta
It is the purpose of this study to purify and investigate some of the properties of triosephosphate isomerase from two unicellular green algae 1 Ankistrodesmus Braunii and Scenedesmus acuminatus, and one filamentous green alga, Chara sp.