Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Isolated Heart"”.
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The role of the arterial glycocalyx in sphingosine-1- phosphate induced cardioprotection in the isolated heart of the Wistar rat
Background: Ischemic heart diseases (IHD) are a leading cause of death among cardiovascular diseases. Unfortunately, the myocardial damage due to ischemia in IHD may be worsened by reperfusion therapy, a phenomenon called ischemic-reperfusion (I/R) injury. Coronary vascular damage is a key feature …
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Extending Function and Applications of Isolated Cardiopulmonary Systems
The use of isolated mammalian hearts has a history that is responsible for a staggering amount of the basic physiological knowledge we have about the cardiovascular system and is a primary gateway between ideas and clinical treatment. Advances in cardiac physiology, surgery, transplantation, …
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Magnesium homeostasis in the mammalian heart
… cationic control of Mg2+ homeostasis in the rat heart. Subsequently, the effects of dietary magnesium on the magnesium, calcium, sodium and potassium content of the heart (and other tissues) in young rats is also investigated. Perfusion of the isolated heart with elevated extracellular Mg2+ (1.2 …
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Cardioregulatory Role of the Abdominal Ganglion of APLYSIA CALIFORNICA
<p>An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood …
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Local pharmacokinetics and pharmacodynamics of angiogenic growth factors in myocardial tissue
… local myocardial PK through a series of ex-vivo isolated heart studies and mathematical analysis, examined the local coupling of PK and PD with an in-vivo ischemic heart model, created a computational model of myocardial PK and PD to predict distribution of growth factors and their biologic …
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Sex differences in the cardiac beta-adrenergic receptor contractile response
… sex differences, studies were performed using isolated perfused hearts from male, intact female and ovariectomized female mice, as well as male and female ventricular myocytes. Female hearts exhibited blunted contractile responses to the &beta-adrenergic receptor agonist isoproterenol (ISO) …
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Melatonin as a novel cardioprotective therapy in pulmonary hypertension
… cardiac function (via echocardiography and the isolated heart Langendorff perfusion model). Results: Plasma oxidative stress was increased in both patients and rats with PH compared with their respective controls. A chronic treatment with melatonin (75ng/L, 4mg/kg or 6mg/kg) starting on the day …
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Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
Coronary heart disease (CHD) is one of the leading causes of death every year with nearly three-fourths of all deaths caused by the disease. The challenge scientists are facing today is discovering new drugs to protect the heart against cellular damage caused by ischemia-reperfusion injury (I-R …
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Studies on the role of GPR55 in cardiovascular physiology and pathophysiology.
… the same signalling pathway as it did in the isolated heart, in both mouse and human-induced pluripotent stem cell-derived cardiomyocytes thus suggesting a translational role for GPR55 in the human heart. In conclusion, despite further research being required, the data presented within this …
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Developing methods for measuring mitochondrial redox status and membrane potential in the isolated perfused heart
… the absorbance of intrinsic chromophores in the isolated perfused heart. The absorbance of mitochondrial cytochromes provides information about reducing equivalent delivery, respiratory flux, tissue oxygenation, and ΔΨ<sub>m</sub> and thus provides a wealth of information about cardiac …
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Differences in the expression of opioid peptides in Dahl salt-resistant and salt-sensitive rats
… mRNA was abundantly present in brain, testis and heart. There was more POMC mRNA in the pituitary tissue of R rats on high salt diet compared with the pituitary of S rats on high salt diet. Differences in POMC mRNA in the pituitary were not observed between R and S on low salt diet. There were no …
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The effect of serum on the hypodynamic frog heart
… the effects of serum and serum fractions on the isolated spontaneously beating frog heart preparation. Initial experiments were performed to develop a sensitive bioassay preparation to test for inotropic agents in serum. The isolated spontaneously beating frog heart was found to be sensitive, …
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Investigating the role of toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury
Ischaemic heart disease remains a significant cause of death throughout the developed world. Although technological advancements and improved health care have significantly reduced mortality rates in the last century, additional research is required. Recently myocardial inflammation has drawn …
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Ethanolamine as a cardioprotective agent in doxorubicin-induced cardiotoxicity
… has previously been shown to protect the isolated heart against ischaemia-reperfusion injury, however, its use as a cardioprotective agent against doxorubicin-induced cardiotoxicity has not been assessed. Therefore, in this study, we investigate the effects of ethanolamine on …
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Investigations into mechanisms of magnesium homeostasis in the isolated rat heart
… is essential for normal functioning of the heart. It is the second most abundant divalent cation in living cells and plays vital roles in cellular regulation. Preservation of intracellular Mg 24 concentration ([Mg24]) is essential in the heart. The concentration of ionized Mg 24 is similar …
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Direkte kardiale Effekte positiv inotroper Pharmaka bei Sepsis-induzierter kardialer Dysfunktion am isoliert perfundierten Rattenherzen
Im Rahmen einer Sepsis kommt es häufig zu einer myokardialen Dysfunktion, der septischen Kardiomyopathie, die den Einsatz positiver Inotropika erfordert. Ziel der Studie ist es, die jeweiligen dosisabhängigen Wirkungen gängiger Inotropika auf die linksventrikuläre Funktion und den …
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Effect of metformin treatment on isolated cardiac function and blood pressure in diabetic and hypertensive rats
… the effect of chronic metformin treatment on isolated cardiac function in rats made diabetic with STZ and secondly to explore the effect of metformin treatment on the hyperinsulinemic status of two rodent models of hypertension, the spontaneously hypertensive rat and the fructose-induced …
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Molecular detection and charcaterisation of biologically relevant free radicals during surgical ischaemia-reperfusion
… sudden increase of diastolic pressure in the heart was noted and reached a maximum of 77 mmHg after 12 min of reperfusion and then gradually decreased to 51 mmHg after 60 min of reperfusion period but was quicker than in Control group reaching 37 mmHg by the end of the reperfusion period. The …