Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"Isolated GnRH deficiency"”.
-
Uncovering novel genes causing isolated gonadotropin releasing hormone deficiency using runs of homozygosity in outbred families
BACKGROUND: Isolated GnRH Deficiency (IGD) is a rare Mendelian disorder, characterized by absent puberty and infertility. Over 30 causal IGD genes have been discovered, yet only 30-35% of IGD cases have a proven genetic etiology, highlighting the importance of new discovery methods. Homozygosity …
-
NOVEL INSIGHTS INTO GENETIC AND ENVIRONMENTAL DETERMINANTS SHAPING GNRH NEURON BIOLOGY AND RELATED REPRODUCTIVE DISORDERS
… the secretion of gonadotropin-releasing hormone (GnRH), a neuropeptide that stimulates the release of gonadotropins from the pituitary, driving gametogenesis and sex steroid production. GnRH-secreting neurons originate from the olfactory placode during embryogenesis and migrate into the forebrain …