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Showing 1 to 3 of 3 for “"Isoindoline"”.
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Using Small Molecule Tools to Study ATPase Mechanoenzymes
… Minimal modification of the most potent hit, an isoindoline-based compound, resulted in VCP Activator 1 (VA1), a compound that dose-dependently stimulates VCP ATPase activity up to ~3-fold. Cryo-EM studies resulted instructures (~2.9-3.5 Å-resolution) of VCP in apo and ADP-bound states, and …
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Synthesis of mixes ligand metal-organic frameworks for sorption studies
… (L2), 2,2-bis(pyridin-2-ylmethyl)-[5,5-biisoindoline]-1,1-3,3-tetraone (L3), 2,2-bis(pyridin-4-ylmethyl)-[5,5-biisoindoline]-1,1-3,3-tetraone (L4) and 5,5-carbonylbis(2-(pyridin-3-ylmethyl) isoindoline-1,3-dione) (L5). The second part of this study describes the synthesis of seven …
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Asymmetric synthesis of trisubstituted isoindolines and tetrahydropalmatine via tandem 1,2-addition-cyclisation
… access to 1,2,3-trisubstituted isoindolines via a tandem 1,2-addition/cyclisation process was developed. After condensation of SAMP with o-phthalic dicarboxaldehyde, the remaining aldehyde functionality was transformed into different alkenes by Horner-Wadsworth-Emmons reaction. …