Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Isoform 1"”.
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Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
… directly activated by cAMP (Epac). Epac has two isoforms, the ubiquitously expressed Epac1 and the more tissue restricted Epac2. The biological functions of Epac1 have been revealed, including cardiac stress, chronic pain, cancer and infections. However, the roles of Epac1 in energy balance are …
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Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
… directly activated by cAMP (Epac). Epac has two isoforms, the ubiquitously expressed Epac1 and the more tissue restricted Epac2. The biological functions of Epac1 have been revealed, including cardiac stress, chronic pain, cancer and infections. However, the roles of Epac1 in energy balance are …
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ARNT isoforms differentially regulate cancer cell growth through a p53-dependent mechanism.
… on simultaneous suppression of the two ARNT isoforms, isoform 1 and 3, and therefore precluded the isolated examination of each isoform’s function. We show here that lymphoid malignancies exhibit higher levels of ARNT isoform 1 compared to ARNT isoform 3. However, normal T and B lymphocytes …
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Investigation of ARNT isoform-specific regulation of AHR signaling
… is alternatively spliced into two distinct isoforms, isoform 1 and 3. Although ARNT is found to be critical in immunity, xenobiotic, and hypoxic response, ARNT isoform-specific function has yet to be investigated. We previously demonstrated that primary lymphocytes express both of these …
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The role of tapasin and its isoforms in antigen presentation and tumor immunity
… responses. The first described-spliced tapasin (“isoform 1”) plays a critical role in MHC-I antigen presentation by facilitating peptide loading onto MHC-I molecules in the endoplasmic reticulum (ER). This thesis examines the expression, localization and function of two novel, …
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Investigating The Dysregulation And Therapeutic Potential Of Neuroprotective Stress Response Proteins In Huntington’s Disease
… models of HD. I find that overexpressing RBM3 isoform 1 or RTN3 in the striatum of HD mice does not rescue disease phenotypes. I also find that overexpressing RBM3 isoform 1 or 2 in the striatum does not increase RTN3 levels as expected. Further, I provide evidence that cold stress and RBM3 …
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Understanding the Role of Delta-catenin in Virus-Positive Merkel Cell Carcinoma
… We found that while HFFs predominantly express isoform 1, a mesenchymal marker, MCC cells primarily express isoform 3, an epithelial marker. However, overexpression of delta-catenin isoform 1 in VP-MCC cells failed to restore ST binding. These results suggest that the MCC cell of origin may …
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DISSECTING THE ROLE OF NEDD4 HECT E3 LIGASE AND ITS ISOFORMS IN CANCER
… we noticed the presence of few putative NEDD4 isoforms recognized by anti-NEDD4 antibody, and, hypothesizing a possible contribute to the proliferation phenotype, we decided to characterize them. The existence of alternative splice variants of NEDD4 has been reported in online databases, but …
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Uncovering Regulators of Whole-Body Metabolism by Chemoproteomic Profiling of the Adipocyte Secretome
… Despite the lack of a signal peptide, the long isoform (isoform 1) of C11orf54 was validated to be a bona fide secreted factor, while the short isoform (isoform 2) was predominantly intracellular. Functional studies with mice lacking C11orf54 isoform 1 suggest that it may regulate total body …
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A Functional Genomics Approach to the Plant Soluble Pyrophosphatase Family
… genome encodes six soluble pyrophosphatase isoforms (ASP1, ASP2A, ASP2B, ASP3, ASP4 and ASP5), which were shown to be highly conserved both in nucleic and in amino acid sequences. Microscopic analysis of leaves transiently transformed with C-terminal GFP tagged A. thaliana sPPase proteins …
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Zum antioxidativen Verteidigungssystem bei Mesembryanthemum crystallinum
… mit den bereits bekannten Sequenzen von fünf Isoformen der Ascorbat Peroxidase (APX), Katalase und Cu/Zn-Superoxid Dismutase (SOD) stand damit das Instrumentarium für Expressionsanalysen am überwiegenden Teil der beteiligten Enzyme zur Verfügung. Bei Pflanzen, die Salzstress ausgesetzt waren …
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Mechanisms Regulating The P120-Catenin/Kaiso Pathway
… p120-catenin protein stability, especially p120 isoform-1, through mechanisms shared with b-catenin. Exogenous expression of destruction-complex components such as GSK3b or Axin promotes p120-catenin degradation, and consequently, is able to rescue developmental phenotypes resulting from p120 …
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Myeloid-Specific ARNT Signaling Drives Sex-Based Differences in Acrolein-Induced Pulmonary Toxicity
… overexpression of Arnt-a (homolog of human ARNT isoform 1), this study characterizes both the both the initiation (24-hours) and resolution (5-day) phases of acrolein-induced acute lung injury, incorporating both sex and age as key biological variables and potential determinants of the severity …
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Single Nucleotide Polymorphisms Linked to Essential Hypertension in Kasigau, Kenya
<p>Hypertension, or high blood pressure (BP), is an ever-growing epidemic in the developing world. Understanding the genetics behind essential hypertension (EH), or hypertension with no known cause, is especially important. In this study, three single nucleotide polymorphisms (SNPs) known to be …