Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Isobaric tags for relative and absolute quantitation (iTRAQ)"”.
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THE BIO-MOLECULAR ANALYSIS OF TITANIUM DIOXIDE NANOPARTICLES EXPOSURE ON CARDIOMYOCYTES
… the increasing large number of NPs required for testing has led to the need for new alternative testing strategies via computational means to replace the costly and laborious animal testing. Yet, such testing requires the understanding and identification of relevant safety biological …
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PROTEOMICS INSIGHTS INTO MOLECULAR MECHANISMS OF TRIPTOLIDE AGAINST COLORECTAL CANCER
… cell migration, cell adhesion, protein synthesis and induce alteration of transcription factors in colorectal cancer cell line HCT 116. In my first project, protein alterations of HCT 116 cells treated with triptolide were profiled at a global level, by using Isobaric Tags for Relative and …
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Differential membrane-type matrix metalloproteinase expression in phenotypically defined breast cancer cell lines: Comparison of MT-MMP expression in environmentally-challenged 2D monolayer cultures and 3D multicellular tumour spheroids
… extracellular matrix (ECM), which is essential for tissue structure and transmitting messages between cells. MMPs play an important role in cancer, controlling cell migration, proliferation, apoptosis, regulation of tumour expansion, angiogenesis and invasion. Previous research has indicated …
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Biomarkers of Optic Nerve Head Glial Cell Activation Following Biomechanical Insult
… Primary Open Angle Glaucoma is the most common form of the disease and can be characterized by the slow and irreversible apoptotic death of retinal ganglion cells, a unique optic nerve neuropathy resulting in loss of vision. Increased intra-ocular pressure is known to be a leading risk-factor …
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Analysis of the nuclear proteome of the resurrection plant Xerophyta viscosa (Baker) and its response to dehydration stress
… of dehydration (desiccation), down to 5% relative water content (RWC) and resumes full physiological activity within 80 h of rehydration. A thorough understanding of this phenomenon may provide further insight into possible mechanisms for improving drought tolerance in other plants. In …
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Characterizing and analyzing disease-related omics data using network modeling approaches
… produce biological phenotypes. A number of tools for comprehensive and high-throughput measurements of DNA/RNA, protein and metabolites have been developed. Each of these technologies helps to characterize individual components of the genome, proteome or metabolome and offers a distinct …