Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 163 for “"Islets"”.
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Cryopreservation of pancreatic islets
… this therapy is limited by the availability of islets. Long-term cryopreservation of islets could partially address this limitation but current cryopreservation protocols, which use the toxic cryoprotectant dimethyl sulphoxide (DMSO), achieve suboptimal cryosurvival and are not clinically used. …
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3D bioprinting of pancreatic islets
Hintergrund/Ziel: Um Langzeitkomplikationen bei Diabetes mellitus Typ 1 (T1D) zu verhindern, können Spenderinseln transplantiert werden, was allerdings lebenslange rigorose Immunsuppression erfordert. Durch Verkapselung der Inselzellen kann die Immunsuppression umgangen werden, aber Upscaling ist …
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iPLA2β, ALTERNATIVE SPLICING AND APOPTOSIS OF PANCREATIC ISLETS
… splice variants were compared in human and mouse islets, mouse islet cell lines, and in rat insulinoma (INS1) cells. INS-1 insulinoma cells were treated with thapsigargin to induce ER stress, which can eventually lead to apoptosis. Thapsigarin-treated INS-1 cells exhibited an increase in the ratio …
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Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets
… many years that long-term exposure of pancreatic islets to a high level of free fatty acids (FFA) or glucose negatively modulates islet hormone release, the identities of signals mediating these effects are not yet fully clarified. The overall objective of this study was to investigate signal …
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Insulin-secreting tumors of the islets of Langerhans
Thesis (M.D.)—-Boston University
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Microencapsulated human islets as a therapy for type 1 diabetes
Microencapsulating human islets is a means being explored to overcome the immune mediated destruction of the graft without toxic immunosuppression. Despite promising studies in various animal models, encapsulated human islet transplantation has so far not made an impact in the clinical setting. …
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Somatostatin inhibits insulin release via SSTR2 in the hamster pancreatic islets
… of insulin release. Isolated hamster pancreatic islets were used in the present study to test this hypothesis. Both somatostatin (1-100 nM) and nonpeptide SSTR2 agonist L-779,976 (0.1-100 nM) inhibited insulin release in a dose-dependent manner. Nonpeptide agonists for SSTR1, 3, 4, and 5 at the …
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Development of quantitative methods for quality assessment of islets of Langerhans
Transplantation of isolated islets of Langerhans has promising potential to cure type 1 diabetes by inducing long-term normoglycemia and insulin independence. The feasibility of clinical islet transplantations has been established according to the Edmonton Protocol. However, results are variable, …
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A peptidomic investigation into enteroendocrine cells and islets of humans and mice
… (EECs) of the gastrointestinal (GI) tract and islets of Langerhans (islets) of the pancreas are endocrine cells capable of sensing nutrient intake or the nutrient content of the blood and responding by secreting peptide hormones to control various physiological functions. This thesis focuses on …
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Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
… Thrombomodulin (TM) and CD47, on the surface of islets to promote islet engraftment by controlling thrombotic/inflammatory reactions associated with an immediate blood-mediated inflammatory response (IBMIR). In chapter 3, syngeneic pancreatic islets are engineered with a novel form of TM (SA-TM) …
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Cell coupling and exocytosis measured in intact mouse pancreatic islets Control of {delta}-cell secretion
… to α-, β- and δ-cells in intact mouse pancreatic islets. The maximum rate of β-cell exocytosis during a depolarization to 0 mV was 14 granules/s, <5% of that observed in isolated β-cells. β-cell exocytosis exhibited bell-shaped voltage dependence and peaked at +20 mV. At physiological membrane …
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Eliminating oxygen supply limitations for transplanted microencapsulated islets in the treatment of type 1 diabetes
… Insulin is produced by [beta]-cells in the Islets of Langerhans, which are aggregates of cells averaging about 150 [mu]m in diameter and constituting about 1 to 2% of the pancreas volume. The efficacy of islet transplantation as a treatment for diabetes has been demonstrated in humans by the …
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A Study of Glucose Stimulus Insulin Secretion Coupling using Lean and Obese Mouse Islets of Langerhans
… coupling has been investigated using isolated islets of Langerhans from lean homozygous (+/+) and genetically obese hyperglycaemic (ob/ob) mice. Streptozotocin inhibition of the insulin response to glucose but not glucagon suggests glucose sensitive sites and adenylate cyclase systems to be …
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